Stereocontrolled Synthesis of a Heptose- and Kdo-Containing Common Inner-Core Trisaccharide of Lipopolysaccharides from Multiple Pathogenic Bacteria
文献类型：期刊论文
| 作者 | Li, Jiawei2,3; Gao, Runing2,3; Hao, Tianhui1,2; Li, Tiehai1,2,3 |
| 刊名 | SYNLETT
 |
| 出版日期 | 2024-04-18 |
| 页码 | 5 |
| 关键词 | lipopolysaccharides glycosylation bacterial oligosaccharides heptose Kdo trisaccharides |
| ISSN号 | 0936-5214 |
| DOI | 10.1055/a-2301-2358 |
| 通讯作者 | Li, Tiehai(tiehaili@simm.ac.cn) |
| 英文摘要 | Lipopolysaccharides (LPSs) are major virulence determinants in Gram-negative bacteria and are responsible for many pathophysiological processes during bacterial infections. However, the accessibility of LPS-associated oligosaccharides for infectious mechanism study and vaccine development remains challenging. We report an efficient stereo controlled approach for the synthesis of a common inner-core trisaccharide containing difficult-to-access, rare, higher-carbonsugars: a heptose (Hep) and 3-deoxy-alpha-D-manno-oct-2-ulosonic acid(Kdo). Key features include comprehensive elaboration of a practical synthesis of versatile Hep and Kdo building blocks, and stereoselective assembly of an inner-core trisaccharide from multiple pathogenic bacteriaY |
| WOS关键词 | 3-DEOXY-D-MANNO-2-OCTULOSONIC ACID KDO ; STEREOSELECTIVE-SYNTHESIS ; CHEMICAL-SYNTHESIS ; GLYCOSYL ; VACCINE ; TETRASACCHARIDE ; GLYCOCONJUGATE ; STRATEGY ; GLYCANS ; ROUTE |
| 资助项目 | Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001205288600002 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310632]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Tiehai |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Rd, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jiawei,Gao, Runing,Hao, Tianhui,et al. Stereocontrolled Synthesis of a Heptose- and Kdo-Containing Common Inner-Core Trisaccharide of Lipopolysaccharides from Multiple Pathogenic Bacteria[J]. SYNLETT,2024:5. |
| APA | Li, Jiawei,Gao, Runing,Hao, Tianhui,&Li, Tiehai.(2024).Stereocontrolled Synthesis of a Heptose- and Kdo-Containing Common Inner-Core Trisaccharide of Lipopolysaccharides from Multiple Pathogenic Bacteria.SYNLETT,5. |
| MLA | Li, Jiawei,et al."Stereocontrolled Synthesis of a Heptose- and Kdo-Containing Common Inner-Core Trisaccharide of Lipopolysaccharides from Multiple Pathogenic Bacteria".SYNLETT (2024):5. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。