Diverse roles of pontine NPS- expressing neurons in sleep regulation
文献类型：期刊论文
| 作者 | Xing, Lijuan5; Zou, Xianlin5; Yin, Chen5; Webb, John M.5; Shi, Guangsen4; Ptacek, Louis J.3; Fu, Ying- Hui1,2,3,5 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2024-02-27 |
| 卷号 | 121期号:9页码:10 |
| 关键词 | NPS parabrachial nucleus central gray of the pons sleep neural circuitry |
| ISSN号 | 0027-8424 |
| DOI | 10.1073/pnas.2320276121 |
| 通讯作者 | Fu, Ying- Hui(Ying-Hui.Fu@ucsf.edu) |
| 英文摘要 | Neuropeptide S (NPS) was postulated to be a wake- promoting neuropeptide with unknown mechanism, and a mutation in its receptor (NPSR1) causes the short sleep duration trait in humans. We investigated the role of different NPS+ nuclei in sleep/wake regulation. Loss- of- function and chemogenetic studies revealed that NPS+ neurons in the parabrachial nucleus (PB) are wake- promoting, whereas peri-locus coeruleus (peri-LC) NPS+ neurons are not important for sleep/wake modulation. Further, we found that a NPS+ nucleus in the central gray of the pons (CGPn) strongly promotes sleep. Fiber photometry recordings showed that NPS+ neurons are wake- active in the CGPn and wake/REM-sleep active in the PB and peri-LC. Blocking NPS-NPSR1 signaling or knockdown of Nps supported the function of the NPS-NPSR1 pathway in sleep/wake regulation. Together, these results reveal that NPS and NPS+ neurons play dichotomous roles in sleep/wake regulation at both the molecular and circuit levels. |
| WOS关键词 | NEUROPEPTIDE-S ; REM-SLEEP ; HYPOCRETIN OREXIN ; NEURAL CIRCUITRY ; IN-VIVO ; MICE ; ANTAGONIST ; CONTRIBUTE ; BEHAVIOR ; AROUSAL |
| 资助项目 | NIH[NS117929] ; NIH[NS072360] ; NIH[NS104782] ; NIH[P30 DK063720] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001206471000002 |
| 出版者 | NATL ACAD SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310653]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fu, Ying- Hui |
| 作者单位 | 1.Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA 2.Univ Calif San Francisco, Kavli Inst Fundamental Neurosci, San Francisco, CA 94143 USA 3.Univ Calif San Francisco, Weill Inst Neurosci, Dept Neurol, San Francisco, CA 94143 USA 4.Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Chinese Acad Sci, Zhongshan 528400, Peoples R China 5.Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA |
| 推荐引用方式 GB/T 7714 | Xing, Lijuan,Zou, Xianlin,Yin, Chen,et al. Diverse roles of pontine NPS- expressing neurons in sleep regulation[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2024,121(9):10. |
| APA | Xing, Lijuan.,Zou, Xianlin.,Yin, Chen.,Webb, John M..,Shi, Guangsen.,...&Fu, Ying- Hui.(2024).Diverse roles of pontine NPS- expressing neurons in sleep regulation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,121(9),10. |
| MLA | Xing, Lijuan,et al."Diverse roles of pontine NPS- expressing neurons in sleep regulation".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121.9(2024):10. |
入库方式： OAI收割
来源：上海药物研究所
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