Recent Progress of Small Interfering RNA Delivery on the Market and Clinical Stage
文献类型：期刊论文
| 作者 | Guo, Fan3,4; Li, Yan2,3; Yu, Wenjun2,3; Fu, Yuanlei2,3; Zhang, Jing4; Cao, Haiqiang1,2,3 |
| 刊名 | MOLECULAR PHARMACEUTICS
 |
| 出版日期 | 2024-04-17 |
| 页码 | 16 |
| 关键词 | gene therapy small interfering RNAs deliveryplatforms hepatic targeting extrahepatic targeting |
| ISSN号 | 1543-8384 |
| DOI | 10.1021/acs.molpharmaceut.3c01158 |
| 通讯作者 | Fu, Yuanlei(ylfu@yimm.ac.cn) ; Zhang, Jing(jing0126@163.com) ; Cao, Haiqiang(caohaiqiang1@simm.ac.cn) |
| 英文摘要 | Small interfering RNAs (siRNAs) are promising therapeutic strategies, and five siRNA drugs have been approved by the Food and Drug Administration (FDA) and the European Commission (EC). This marks a significant milestone in the development of siRNA for clinical applications. The approved siRNA agents can effectively deliver siRNAs to the liver and treat liver-related diseases. Currently, researchers have developed diverse delivery platforms for transporting siRNAs to different tissues such as the brain, lung, muscle, and others, and a large number of siRNA drugs are undergoing clinical trials. Here, these delivery technologies and the latest advancements in clinical applications are summarized, and this Review provides a concise overview of the strategies employed for siRNA delivery to both hepatic and extrahepatic tissues. |
| WOS关键词 | TRANSTHYRETIN-MEDIATED AMYLOIDOSIS ; MESOPOROUS SILICA NANOPARTICLES ; LIPID NANOPARTICLES ; SYSTEMIC DELIVERY ; IN-VIVO ; HATTR AMYLOIDOSIS ; GUIDE STRAND ; SIRNA ; VUTRISIRAN ; PATISIRAN |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001204959700001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310659]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fu, Yuanlei; Zhang, Jing; Cao, Haiqiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Shandong 264000, Peoples R China 4.Binzhou Med Univ, Sch Pharm, Shandong 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Fan,Li, Yan,Yu, Wenjun,et al. Recent Progress of Small Interfering RNA Delivery on the Market and Clinical Stage[J]. MOLECULAR PHARMACEUTICS,2024:16. |
| APA | Guo, Fan,Li, Yan,Yu, Wenjun,Fu, Yuanlei,Zhang, Jing,&Cao, Haiqiang.(2024).Recent Progress of Small Interfering RNA Delivery on the Market and Clinical Stage.MOLECULAR PHARMACEUTICS,16. |
| MLA | Guo, Fan,et al."Recent Progress of Small Interfering RNA Delivery on the Market and Clinical Stage".MOLECULAR PHARMACEUTICS (2024):16. |
入库方式： OAI收割
来源：上海药物研究所
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