Difunctionalization of gem-difluoroalkenes for amination and heteroarylation via metal-free photocatalysis
文献类型：期刊论文
| 作者 | Zhong, Yuanchen2,3; Zhuang, Zhen1,2; Zhang, Xiaofei2; Xu, Bin3; Yang, Chunhao1,2
|
| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2024-04-30 |
| 卷号 | 60期号:36页码:4830-4833 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/d4cc00528g |
| 通讯作者 | Xu, Bin(xubin@shu.edu.cn) ; Yang, Chunhao(chyang@simm.ac.cn) |
| 英文摘要 | gem-Difluoroalkenes are widely used building blocks in fluorine chemistry. Herein, a metal-free photocatalytic amination and heteroarylation method of gem-difluoroalkenes with heteroaryl carboxylic acid oxime esters as substrates is reported. This environmentally benign reaction proceeds via radical-radical cross-coupling in energy-transfer-mediated photocatalysis and can be used in the rapid construction of heteroaryl difluoroethylamine scaffolds and late-stage modification of complex pharmaceutical structures. |
| WOS关键词 | INHIBITORS ; FLUORINE ; ALKENES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001202433600001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310753]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Bin; Yang, Chunhao |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhong, Yuanchen,Zhuang, Zhen,Zhang, Xiaofei,et al. Difunctionalization of gem-difluoroalkenes for amination and heteroarylation via metal-free photocatalysis[J]. CHEMICAL COMMUNICATIONS,2024,60(36):4830-4833. |
| APA | Zhong, Yuanchen,Zhuang, Zhen,Zhang, Xiaofei,Xu, Bin,&Yang, Chunhao.(2024).Difunctionalization of gem-difluoroalkenes for amination and heteroarylation via metal-free photocatalysis.CHEMICAL COMMUNICATIONS,60(36),4830-4833. |
| MLA | Zhong, Yuanchen,et al."Difunctionalization of gem-difluoroalkenes for amination and heteroarylation via metal-free photocatalysis".CHEMICAL COMMUNICATIONS 60.36(2024):4830-4833. |
入库方式： OAI收割
来源：上海药物研究所
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