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Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder

文献类型：期刊论文

作者Xie, Zuoquan6; Huang, Jingjing5; Sun, Guangqiang3,4; He, Shen5; Luo, Zhiyu4; Zhang, Linna5; Li, Liang4; Yao, Min6; Du, Chen4; Yu, Wenjuan5
刊名PSYCHIATRY RESEARCH
出版日期2024-04-01
卷号334页码:12
关键词Major depressive disorder Peripheral changes Gut microbiota Immune phenotyping Multiomics Biomarkers
ISSN号0165-1781
DOI10.1016/j.psychres.2024.115804
通讯作者Li, Huafang(lihuafang@smhc.org.cn) ; Geng, Meiyu(mygeng@simm.ac.cn)
英文摘要Major depressive disorder (MDD) involves systemic changes in peripheral blood and gut microbiota, but the current understanding is incomplete. Herein, we conducted a multi-omics analysis of fecal and blood samples obtained from an observational cohort including MDD patients (n = 99) and healthy control (HC, n = 50). 16S rRNA sequencing of gut microbiota showed structural alterations in MDD, as characterized by increased Enterococcus. Metagenomics sequencing of gut microbiota showed substantial functional alterations including upregulation in the superpathway of the glyoxylate cycle and fatty acid degradation and downregulation in various metabolic pathways in MDD. Plasma metabolomics revealed decreased amino acids and bile acids, together with increased sphingolipids and cholesterol esters in MDD. Notably, metabolites involved in arginine and proline metabolism were decreased while sphingolipid metabolic pathway were increased. Mass cytometry analysis of blood immune cell subtypes showed rises in proinflammatory immune subsets and declines in antiinflammatory immune subsets in MDD. Furthermore, our findings revealed disease severity-related factors of MDD. Interestingly, we classified MDD into two immune subtypes that were highly correlated with disease relapse. Moreover, we established discriminative signatures that differentiate MDD from HC. These findings contribute to a comprehensive understanding of the MDD pathogenesis and provide valuable resources for the discovery of biomarkers.
WOS关键词B-CELLS ; INFLAMMATION ; METABOLOMICS ; METAANALYSIS ; ANXIETY ; STRESS ; BLOOD
资助项目Natural Science Foundation of China for Innovation Research Group[81821005] ; Shanghai Municipal Science and Technology Major Project ; Clinical Research Plan of SHDC[SHDC2020CR2053B] ; Lingang Laboratory[LG202101-01-01]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001199787500001
出版者ELSEVIER IRELAND LTD
源URL[http://119.78.100.183/handle/2S10ELR8/310780]  
专题新药研究国家重点实验室
通讯作者Li, Huafang; Geng, Meiyu
作者单位1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, 600 South Wanping Rd, Shanghai 200030, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
4.Green Valley Shanghai Pharmaceut Technol Co Ltd, Shanghai 201203, Peoples R China
5.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Xie, Zuoquan,Huang, Jingjing,Sun, Guangqiang,et al. Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder[J]. PSYCHIATRY RESEARCH,2024,334:12.
APA Xie, Zuoquan.,Huang, Jingjing.,Sun, Guangqiang.,He, Shen.,Luo, Zhiyu.,...&Geng, Meiyu.(2024).Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder.PSYCHIATRY RESEARCH,334,12.
MLA Xie, Zuoquan,et al."Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder".PSYCHIATRY RESEARCH 334(2024):12.

入库方式： OAI收割

来源：上海药物研究所

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