Palladium(II)-Catalyzed Tandem γ-C(sp2)-H Arylation and Cyclization for the Construction of Natural Product-Like Polycyclic Fused ortho-Quinone Scaffolds
文献类型：期刊论文
| 作者 | Li, Xingjun3,4; Chen, Yu2,3; Xie, Xiong2,3; Li, Jing2,3 ; Wang, Jiang1,3; Liu, Hong2,3,4
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2024-04-12 |
| 页码 | 6 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.4c00900 |
| 通讯作者 | Wang, Jiang(jwang@lglab.ac.cn) ; Liu, Hong(hliu@simm.ac.cn) |
| 英文摘要 | Here, we report a novel strategy for the direct construction of polycyclic fused ortho-quinone scaffolds through palladium(II)-catalyzed tandem gamma-C(sp(2))-H arylation and cyclization of arylglyoxals with aryl iodides. This transformation features unique tandem transient directing of gamma-C(sp(2))-H arylation and cyclization reaction mode, broad substrate scope, especially for the aromatic substrates containing oxygen and sulfur atoms, and avoiding the common issue of aromatization due to the construction of the hexatomic ring. |
| WOS关键词 | ONE-POT SYNTHESIS ; REGIOSELECTIVE OXIDATION ; PHENOLS |
| 资助项目 | National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[22337003] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[82322063] ; National Natural Science Foundation of China[22177124] ; National Natural Science Foundation of China[2022YFA1302900] ; National Natural Science Foundation of China[LG-GG-202204-02] ; National Key R&D Program of China[23XD1460300] ; Program of Shanghai Academic Research Leader |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001203967400001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310783]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Jiang; Liu, Hong |
| 作者单位 | 1.Lingang Lab, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.China Pharmaceut Univ, Sch Pharm, Nanjing 211198, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xingjun,Chen, Yu,Xie, Xiong,et al. Palladium(II)-Catalyzed Tandem γ-C(sp2)-H Arylation and Cyclization for the Construction of Natural Product-Like Polycyclic Fused ortho-Quinone Scaffolds[J]. ORGANIC LETTERS,2024:6. |
| APA | Li, Xingjun,Chen, Yu,Xie, Xiong,Li, Jing,Wang, Jiang,&Liu, Hong.(2024).Palladium(II)-Catalyzed Tandem γ-C(sp2)-H Arylation and Cyclization for the Construction of Natural Product-Like Polycyclic Fused ortho-Quinone Scaffolds.ORGANIC LETTERS,6. |
| MLA | Li, Xingjun,et al."Palladium(II)-Catalyzed Tandem γ-C(sp2)-H Arylation and Cyclization for the Construction of Natural Product-Like Polycyclic Fused ortho-Quinone Scaffolds".ORGANIC LETTERS (2024):6. |
入库方式： OAI收割
来源：上海药物研究所
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