Anti-Inflammatory Salicin Derivatives from the Barks of Salix tetrasperma
文献类型：期刊论文
| 作者 | Wu, Pei-Qian2; Li, Ying1; Ren, Yu-Hao2; Zhou, Jun-Su2; Liu, Qun-Fang2 ; Wu, Yan2; Yu, Jin-Hai1; Zhou, Bin1,2; Yue, Jian-Min1,2
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2024-04-11 |
| 卷号 | 72期号:16页码:9215-9226 |
| 关键词 | Salix tetrasperma salicinderivatives structural elucidation anti-inflammatoryactivity |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.4c01061 |
| 通讯作者 | Zhou, Bin(zbbrush@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | The genus Salix L. is traditionally used in folk medicine to alleviate pain caused by various kinds of inflammation. In the present study, 10 undescribed salicin derivatives along with 5 known congeners were isolated from the barks of Salix tetrasperma, and their structures were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, electronic circular dichroism (ECD) calculations, and chemical conversions. Compounds 4-6 significantly inhibited NO production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, and the most active 4 obviously suppressed the production of IL-1 beta and IL-6 and decreased iNOS and COX-2 expression in a dose-dependent manner. Further Western blotting analysis revealed that the anti-inflammatory mechanism of 4 is possibly mediated through the MAPK and NF-kappa B signaling pathways. |
| WOS关键词 | NF-KAPPA-B ; PHENOLIC GLYCOSIDES ; INFLAMMATION ; LEAVES |
| 资助项目 | National Natural Science Foundation of China[82322064] ; National Natural Science Foundation of China[22107106] ; National Natural Science Foundation of China[22177121] ; Shanghai Municipal Science and Technology Major Project, National Natural Science Foundation of China[SYS202205] ; Shandong Laboratory Program |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:001201352000001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310795]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Bin; Yue, Jian-Min |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Pei-Qian,Li, Ying,Ren, Yu-Hao,et al. Anti-Inflammatory Salicin Derivatives from the Barks of Salix tetrasperma[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2024,72(16):9215-9226. |
| APA | Wu, Pei-Qian.,Li, Ying.,Ren, Yu-Hao.,Zhou, Jun-Su.,Liu, Qun-Fang.,...&Yue, Jian-Min.(2024).Anti-Inflammatory Salicin Derivatives from the Barks of Salix tetrasperma.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,72(16),9215-9226. |
| MLA | Wu, Pei-Qian,et al."Anti-Inflammatory Salicin Derivatives from the Barks of Salix tetrasperma".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 72.16(2024):9215-9226. |
入库方式： OAI收割
来源：上海药物研究所
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