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The influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity

文献类型：期刊论文

作者Luo, Guoshuai7; Jing, Yifan7; Yang, Jie3,4,5,6; Wang, Shuo7; Xuekelaiti, Zaimina7; Yao, Cong7; Gao, Ying7; Chen, Hongli2; Sun, Daliang7; Li, Jie7
刊名JOURNAL OF NEURAL TRANSMISSION
出版日期2024-05-02
页码13
关键词Depression severity Gender differences Psychotic major depression Severe anxiety Thyroid hormones
ISSN号0300-9564
DOI10.1007/s00702-024-02781-3
通讯作者Sun, Daliang(sundaliang@tmu.edu.cn) ; Li, Jie(jieli@tmu.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要BackgroundPsychotic major depression (PMD) is characterized by major depressive disorder (MDD) accompanied by delusions or hallucinations. While the prevalence of PMD and its association with anxiety have been studied, gender-specific differences and the role of thyroid hormones in PMD-related anxiety remain less explored.MethodsA total of 1718 first-episode and drug-na & iuml;ve MDD patients was assessed for the presence of PMD and severe anxiety. Clinical assessments, including Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impressions-Severity (CGI-S) scale, were conducted to assess depression, anxiety, psychotic symptoms, and clinical severity, respectively. Blood samples were collected to measure thyroid function parameters.ResultsThe prevalence of severe anxiety was higher in PMD patients compared to non-psychotic MDD patients (71.3% vs. 5.3%). No significant gender differences were observed in the prevalence of severe anxiety among PMD patients. However, elevated thyroid-stimulating hormone (TSH) levels and increased depression severity (HAMD scores) were identified as independent risk factors for severe anxiety in female PMD patients. In contrast, no significant risk factors were found in male PMD patients. The area under the receiver operating characteristic (AUCROC) analysis revealed that the HAMD score and TSH level showed acceptable discriminatory capacity for distinguishing between female PMD patients with and without severe anxiety.ConclusionThis study highlights the heightened prevalence of severe anxiety in PMD patients, with TSH levels and depression severity emerging as gender-specific risk factors for anxiety in females. These findings suggest the importance of thyroid hormone assessment and tailored interventions for managing anxiety in female PMD patients. Severe anxiety is more prevalent in individuals with psychotic major depression compared to non-psychotic major depression.Thyroid-stimulating hormone (TSH) levels emerge as an independent risk factor for severe anxiety, specifically in female PMD patients.Depression severity, as measured by Hamilton Depression Rating Scale (HAMD) scores, significantly influences severe anxiety in female PMD patients.
收录类别SCI
WOS关键词HAMILTON RATING-SCALE ; DISORDER ; HYPERTHYROIDISM ; HYPOTHYROIDISM ; PREVALENCE ; ASSOCIATIONS ; NEUROTICISM ; VALIDATION ; FEATURES ; VERSION
资助项目National Natural Science Foundation of China
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001216846800001
出版者SPRINGER WIEN
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/47741]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Sun, Daliang; Li, Jie; Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.TianGong Univ, State Key Lab Separat Membrane & Membrane Proc, Tianjin 300387, Peoples R China
3.Tianjin Inst Hepatobiliary Dis, Tianjin, Peoples R China
4.Artificial Cell Engn Technol Res Ctr, Tianjin, Peoples R China
5.Tianjin Key Lab Extracorporeal Life Support Crit D, Tianjin, Peoples R China
6.Third Cent Hosp Tianjin, 83 Jintang Rd, Tianjin 300170, Peoples R China
7.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Mental Hlth Ctr, 13 Liulin Rd, Tianjin 300222, Peoples R China
推荐引用方式
GB/T 7714		 Luo, Guoshuai,Jing, Yifan,Yang, Jie,et al. The influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity[J]. JOURNAL OF NEURAL TRANSMISSION,2024:13.
APA Luo, Guoshuai.,Jing, Yifan.,Yang, Jie.,Wang, Shuo.,Xuekelaiti, Zaimina.,...&Zhang, Xiangyang.(2024).The influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity.JOURNAL OF NEURAL TRANSMISSION,13.
MLA Luo, Guoshuai,et al."The influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity".JOURNAL OF NEURAL TRANSMISSION (2024):13.

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来源：心理研究所

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