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The Impact of Prolonged Duration of Untreated Illness on Clinical Correlates in Chronic Schizophrenia: Exploring the Relationship With Suicide Risk

文献类型：期刊论文

作者Zhang, Ke5; Wang, Chenxi4; Gou, Lei5; Li, Yaxi3; Li, Cui2; Luo, Guoshuai5; Zhang, Xiangyang1
刊名PSYCHIATRY INVESTIGATION
出版日期2024-04-01
卷号21期号:4页码:422-432
关键词Duration of untreated illness Chronic schizophrenia Clinical correlates Cognitive function Suicide Body mass index.
ISSN号1738-3684
DOI10.30773/pi.2023.0384
通讯作者Luo, Guoshuai(luoguoshuai_tijmu@126.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Objective Studies on duration of untreated psychosis are common in patients with schizophrenia, but few studies have investigated the relationship between duration of untreated illness (DUI) and suicide, especially in patients with chronic schizophrenia. Therefore, we intended to investigate the relationship between DUI and suicide and clinical correlates in patients with chronic schizophrenia. Methods A total of 1,555 Chinese patients with chronic schizophrenia were enrolled in this study. DUI was measured in years, reflecting the prolonged untreated periods observed in this population. Clinical correlates were assessed, including symptoms, cognitive functioning, and body mass index. Suicidal ideation and attempts were also examined. Statistical analyses, including multivariate models, were employed to investigate the associations between DUI and clinical correlates while controlling for potential confounders. Results The study revealed a significant proportion (23.3%) of patients with chronic schizophrenia in China received their first treatment after a 4-year delay, with the longest untreated duration reaching 39 years. Patients with longer DUI exhibited more severe negative symptoms, lower immediate memory scores, a higher likelihood of being overweight, and surprisingly, a reduced likelihood of suicidal ideation and attempts. Each additional year of untreated illness was associated with a 3% decrease in the risk of suicidal ideation and attempts. Conclusion The findings underscore the prevalence of extended untreated periods in Chinese patients with chronic schizophrenia and highlight the impact of DUI on negative symptoms, cognitive function, and body weight. Intriguingly, a longer DUI was associated with a lower risk of suicidal ideation and attempts. Psychiatry Investig 2024;21(4):422-432
收录类别SCI
WOS关键词INSOMNIA SEVERITY INDEX ; 1ST EPISODE PSYCHOSIS ; COGNITIVE IMPAIRMENT ; NEGATIVE SYMPTOMS ; RURAL CHINA ; SCALE ; PEOPLE ; INTERVENTION ; EPIDEMIOLOGY ; INDIVIDUALS
资助项目National Natural Science Foundation of China[81973759]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001222113400011
出版者KOREAN NEUROPSYCHIATRIC ASSOC
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/47753]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Luo, Guoshuai; Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Nanjing Tech Vocat Coll, Dept Civil Engn, Nanjing, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
4.Tianjin Chest Hosp, Dept Resp & Crit Care Med, Tianjin, Peoples R China
5.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Lab Biol Psychiat,Mental Hlth Ctr, Tianjin 300222, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Ke,Wang, Chenxi,Gou, Lei,et al. The Impact of Prolonged Duration of Untreated Illness on Clinical Correlates in Chronic Schizophrenia: Exploring the Relationship With Suicide Risk[J]. PSYCHIATRY INVESTIGATION,2024,21(4):422-432.
APA Zhang, Ke.,Wang, Chenxi.,Gou, Lei.,Li, Yaxi.,Li, Cui.,...&Zhang, Xiangyang.(2024).The Impact of Prolonged Duration of Untreated Illness on Clinical Correlates in Chronic Schizophrenia: Exploring the Relationship With Suicide Risk.PSYCHIATRY INVESTIGATION,21(4),422-432.
MLA Zhang, Ke,et al."The Impact of Prolonged Duration of Untreated Illness on Clinical Correlates in Chronic Schizophrenia: Exploring the Relationship With Suicide Risk".PSYCHIATRY INVESTIGATION 21.4(2024):422-432.

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来源：心理研究所

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