Temporal interference stimulation targets deep primate brain
文献类型：期刊论文
| 作者 | Liu, Ruobing3,4; Zhu, Guanyu2; Wu, Zhengping1; Gan, Yifei2; Zhang, Jianguo2; Liu, Jiali3,4 ; Wang, Liang3,4
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| 刊名 | NEUROIMAGE
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| 出版日期 | 2024-05-01 |
| 卷号 | 291页码:12 |
| 关键词 | Temporal interference Deep brain stimulation Intracranial eeg model-based simulation electric field |
| ISSN号 | 1053-8119 |
| DOI | 10.1016/j.neuroimage.2024.120581 |
| 通讯作者 | Wang, Liang(lwang@psych.ac.cn) |
| 英文摘要 | Temporal interference (TI) stimulation, a novel non-invasive stimulation strategy, has recently been shown to modulate neural activity in deep brain regions of living mice. Yet, it is uncertain if this method is applicable to larger brains and whether the electric field produced under traditional safety currents can penetrate deep regions as observed in mice. Despite recent model-based simulation studies offering positive evidence at both macro- and micro-scale levels, the absence of electrophysiological data from actual brains hinders comprehensive understanding and potential application of TI. This study aims to directly measure the spatiotemporal properties of the interfered electric field in the rhesus monkey brain and to validate the effects of TI on the human brain. Two monkeys were involved in the measurement, with implantation of several stereo-electroencephalography (SEEG) depth electrodes. TI stimulation was applied to anesthetized monkeys using two pairs of surface electrodes at differing stimulation parameters. Model-based simulations were also conducted and subsequently compared with actual recordings. Additionally, TI stimulation was administered to patients with motor disorders to validate its effects on motor symptoms. Through the integration of computational electric field simulation with empirical measurements, it was determined that the temporally interfering electric fields in the deep central regions are capable of attaining a magnitude sufficient to induce a subthreshold modulation effect on neural signals. Additionally, an improvement in movement disorders was observed as a result of TI stimulation. This study is the first to systematically measure the TI electric field in living non -human primates, offering empirical evidence that TI holds promise as a more focal and precise method for modulating neural activities in deep regions of a large brain. This advancement paves the way for future applications of TI in treating neuropsychiatric disorders. |
| 收录类别 | SCI |
| 资助项目 | National Natural Science Foundation of China[32020103009] ; National Natural Science Foundation of China[82201634] ; STI2030-Major Projects[2022ZD0205000] ; Ministry Key Project[GW0890006] |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:001219567900001 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 资助机构 | National Natural Science Foundation of China ; STI2030-Major Projects ; Ministry Key Project |
| 源URL | [http://ir.psych.ac.cn/handle/311026/47759]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Wang, Liang |
| 作者单位 | 1.Sanjiang Univ, Sch Innovat, Nanjing, Peoples R China 2.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ruobing,Zhu, Guanyu,Wu, Zhengping,et al. Temporal interference stimulation targets deep primate brain[J]. NEUROIMAGE,2024,291:12. |
| APA | Liu, Ruobing.,Zhu, Guanyu.,Wu, Zhengping.,Gan, Yifei.,Zhang, Jianguo.,...&Wang, Liang.(2024).Temporal interference stimulation targets deep primate brain.NEUROIMAGE,291,12. |
| MLA | Liu, Ruobing,et al."Temporal interference stimulation targets deep primate brain".NEUROIMAGE 291(2024):12. |
入库方式： OAI收割
来源：心理研究所
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