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U-shaped association between fasting blood glucose and suicide attempts in Chinese patients with first-episode drug-na?ve major depressive disorder

文献类型：期刊论文

作者Liu, Junjun3,4,5; Zhang, Guangya4; Jia, Fengnan3,4; Yuan, Hsinsung5; Wang, Qingyuan2; Li, Chuanwei4; Yang, Ruchang3,4; Yue, Yan3,4; Zhang, Xiaobin4; Ye, Gang4
刊名BMC PSYCHIATRY
出版日期2024-05-21
卷号24期号:1页码:12
关键词Association Fasting blood glucose Suicide attempt Major depressive disorder Non-linear relationship
DOI10.1186/s12888-024-05818-9
通讯作者Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background Evidence regarding the relationship between fasting blood glucose (FBG) and suicide attempts (SA) in patients with major depressive disorder (MDD) was limited. Therefore, the objective of this research was to investigate whether FBG was independently related to SA in Chinese patients with first-episode drug-na & iuml;ve (FEDN) MDD after adjusting for other covariates.Methods The present study was a cross-sectional study. A total of 1718 participants (average age: 34.9 +/- 12.4 years, 65.8% females) with FEDN MDD were involved in a hospital in China from September 2016 to December 2018. Multiple logistic regression analysis and smooth curve fitting were used to estimate the association between FBG and the risk of SA. The threshold effect was examined by the two-piecewise linear regression model. Interaction and stratified analyses were conducted according to sex, education, marital status, comorbid anxiety, and psychotic symptoms.Results The prevalence of SA in patients with FEDN MDD was 20.1%. The result of fully adjusted binary logistic regression showed FBG was positively associated with the risk of SA (odds ratio (OR) = 1.62, 95% CI: 1.13-2.32). Smoothing plots also revealed a nonlinear relationship between FBG and SA, with the inflection point of FBG being 5.34 mmol/l. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 0.53 (0.32-0.88, P = 0.014) and 1.48 (1.04-2.10, P = 0.030), respectively.Conclusions A U-shaped relationship between FBG and SA in FEDN MDD patients was found, with the lowest risk of SA at a FBG of 5.34 mmol/l, indicating that both the lower and higher FBG levels may lead to an increased risk of SA.
收录类别SCI
WOS关键词BRAIN GLUCOSE ; RISK
资助项目Medical Science and Technology Development Foundation, Nanjing Department of Health ; Shanxi Medical University
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001228901200005
出版者BMC
资助机构Medical Science and Technology Development Foundation, Nanjing Department of Health ; Shanxi Medical University
源URL[http://ir.psych.ac.cn/handle/311026/47851]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Du, Xiangdong; Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Nanjing Med Univ, Clin Med Coll 2, Clin Med Dept, Nanjing 211166, Peoples R China
3.Soochow Univ, Med Coll, Suzhou 215137, Peoples R China
4.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Dept Psychiat, Suzhou 215137, Peoples R China
5.Nanjing Meishan Hosp, Nanjing 210041, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Junjun,Zhang, Guangya,Jia, Fengnan,et al. U-shaped association between fasting blood glucose and suicide attempts in Chinese patients with first-episode drug-na?ve major depressive disorder[J]. BMC PSYCHIATRY,2024,24(1):12.
APA Liu, Junjun.,Zhang, Guangya.,Jia, Fengnan.,Yuan, Hsinsung.,Wang, Qingyuan.,...&Zhang, Xiangyang.(2024).U-shaped association between fasting blood glucose and suicide attempts in Chinese patients with first-episode drug-na?ve major depressive disorder.BMC PSYCHIATRY,24(1),12.
MLA Liu, Junjun,et al."U-shaped association between fasting blood glucose and suicide attempts in Chinese patients with first-episode drug-na?ve major depressive disorder".BMC PSYCHIATRY 24.1(2024):12.

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来源：心理研究所

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