Elevated thyroid stimulating hormone and metabolic syndrome risk in patients with first-episode and drug-na?ve major depressive disorder: a large-scale cross-sectional study
文献类型：期刊论文
| 作者 | Zhang, Qiaoyang4; Dong, Guanzhong4; Zhu, Xuanyan4; Cao, Yin3,4; Zhang, Xiangyang1,2
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| 刊名 | BMC PSYCHIATRY
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| 出版日期 | 2024-05-21 |
| 卷号 | 24期号:1页码:7 |
| 关键词 | Metabolic syndrome Depression Thyroid TSH |
| DOI | 10.1186/s12888-024-05847-4 |
| 通讯作者 | Cao, Yin(czeyxlk@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | Background Metabolic syndrome (MetS) is common in major depressive disorder (MDD), but its relationship with thyroid hormones remains unclear. We aimed to examine the association of thyroid hormones and MetS in first-episode drug-na & iuml;ve (FEDN) MDD patients. Methods We recruited 1718 unmedicated MDD patients in this cross-sectional study. MetS was defined based on the 2004 Chinese Diabetes Society Criteria. Serum thyroid hormones including free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), thyroid peroxidase antibodies (TPOAb), and anti-thyroglobulin (TGAb) were examined. We used the logistic regression model to determine risk factors for MetS and examined the performance of the regression model by using the Area Under the Curve (AUC). In addition, we performed the trend test to test whether the results were robust. Results The prevalence of MetS in unmedicated MDD patients was 34.4%. MDD patients with MetS had higher levels of serum TSH, TGAb, and TPOAb (all P < 0.001). Concurrently, serum TSH levels were independent risk factors for MetS in MDD patients (OR:1.49, 95%CI: 1.40-1.58), which could also distinguish MDD patients with and without MetS (AUC was 0.77). Additionally, in the trend test, the results also indicated a similar trend when TSH was used as a categorical variable (P for trend < 0.001). Conclusions This study suggests that TSH levels were independent risk factors for MetS in FEDN MDD patients (OR:1.49). The examination of thyroid function may contribute to the early detection of MetS. |
| 收录类别 | SCI |
| WOS关键词 | FREE THYROXINE CONCENTRATION |
| 资助项目 | Science and Technology Development Program of Nanjing Medical University |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:001228901200006 |
| 出版者 | BMC |
| 资助机构 | Science and Technology Development Program of Nanjing Medical University |
| 源URL | [http://ir.psych.ac.cn/handle/311026/47815]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 通讯作者 | Cao, Yin; Zhang, Xiangyang |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China 3.Nanjing Med Univ, Changzhou Med Ctr, Nanjing, Jiangsu, Peoples R China 4.Nanjing Med Univ, Dept Psychol, Affiliated Changzhou Second Peoples Hosp, Changzhou, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Qiaoyang,Dong, Guanzhong,Zhu, Xuanyan,et al. Elevated thyroid stimulating hormone and metabolic syndrome risk in patients with first-episode and drug-na?ve major depressive disorder: a large-scale cross-sectional study[J]. BMC PSYCHIATRY,2024,24(1):7. |
| APA | Zhang, Qiaoyang,Dong, Guanzhong,Zhu, Xuanyan,Cao, Yin,&Zhang, Xiangyang.(2024).Elevated thyroid stimulating hormone and metabolic syndrome risk in patients with first-episode and drug-na?ve major depressive disorder: a large-scale cross-sectional study.BMC PSYCHIATRY,24(1),7. |
| MLA | Zhang, Qiaoyang,et al."Elevated thyroid stimulating hormone and metabolic syndrome risk in patients with first-episode and drug-na?ve major depressive disorder: a large-scale cross-sectional study".BMC PSYCHIATRY 24.1(2024):7. |
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来源：心理研究所
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