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Altered effective connectivity among face-processing systems in major depressive disorder

文献类型：期刊论文

作者Sheng, Fangrui4,5; Wang, Yun4,5; Li, Ruinan4,5; Li, Xiaoya4,5; Chen, Xiongying4,5; Zhang, Zhifang4,5; Liu, Rui4,5; Zhang, Ling3,4,5,6,7; Zhou, Yuan1,2,4,5; Wang, Gang3,4,5,6,7
刊名JOURNAL OF PSYCHIATRY & NEUROSCIENCE
出版日期2024
卷号49期号:3页码:E145-E156
ISSN号1180-4882
DOI10.1503/jpn.230123
通讯作者Zhang, Ling(13661341082@163.com) ; Zhou, Yuan(zhouyuan@psych.ac.cn) ; Wang, Gang(gangwangdoc@ccmu.edu.cn)
英文摘要Background: Neuroimaging studies have revealed abnormal functional interaction during the processing of emotional faces in patients with major depressive disorder (MDD), thereby enhancing our comprehension of the pathophysiology of MDD. However, it is unclear whether there is abnormal directional interaction among face-processing systems in patients with MDD.Methods: A group of patients with MDD and a healthy control group underwent a face-matching task during functional magnetic resonance imaging. Dynamic causal modelling (DCM) analysis was used to investigate effective connectivity between 7 regions in the face-processing systems. We used a Parametric Empirical Bayes model to compare effective connectivity between patients with MDD and controls.Results: We included 48 patients and 44 healthy controls in our analyses. Both groups showed higher accuracy and faster reaction time in the shape-matching condition than in the face-matching condition. However, no significant behavioural or brain activation differences were found between the groups. Using DCM, we found that, compared with controls, patients with MDD showed decreased self-connection in the right dorsolateral prefrontal cortex (DLPFC), amygdala, and fusiform face area (FFA) across task conditions; increased intrinsic connectivity from the right amygdala to the bilateral DLPFC, right FFA, and left amygdala, suggesting an increased intrinsic connectivity centred in the amygdala in the right side of the face-processing systems; both increased and decreased positive intrinsic connectivity in the left side of the face-processing systems; and comparable task modulation effect on connectivity.Limitations: Our study did not include longitudinal neuroimaging data, and there was limited region of interest selection in the DCM analysis.Conclusion: Our findings provide evidence for a complex pattern of alterations in the face-processing systems in patients with MDD, potentially involving the right amygdala to a greater extent. The results confirm some previous findings and highlight the crucial role of the regions on both sides of face-processing systems in the pathophysiology of MDD.
收录类别SCI
WOS关键词ANTIDEPRESSANT TREATMENT ; PREFRONTAL CORTEX ; EMOTIONAL FACES ; AMYGDALA HYPERACTIVATION ; UNIPOLAR DEPRESSION ; FACIAL EXPRESSIONS ; NEURAL RESPONSE ; BOTTOM-UP ; STIMULI ; ACTIVATION
资助项目Beijing Municipal Science & Technology Commission
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:001225949700001
出版者CMA-CANADIAN MEDICAL ASSOC
资助机构Beijing Municipal Science & Technology Commission
源URL[http://ir.psych.ac.cn/handle/311026/47778]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Zhang, Ling; Zhou, Yuan; Wang, Gang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
3.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Natl Ctr Mental Disorders, Beijing, Peoples R China
5.Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
6.Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China
7.Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China
推荐引用方式
GB/T 7714		 Sheng, Fangrui,Wang, Yun,Li, Ruinan,et al. Altered effective connectivity among face-processing systems in major depressive disorder[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2024,49(3):E145-E156.
APA Sheng, Fangrui.,Wang, Yun.,Li, Ruinan.,Li, Xiaoya.,Chen, Xiongying.,...&Wang, Gang.(2024).Altered effective connectivity among face-processing systems in major depressive disorder.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,49(3),E145-E156.
MLA Sheng, Fangrui,et al."Altered effective connectivity among face-processing systems in major depressive disorder".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 49.3(2024):E145-E156.

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来源：心理研究所

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