Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325
文献类型：期刊论文
| 作者 | Wang, Yi-Ran2,3,4 ; Dong, Yu-Liang3,4; Li, Xiao-Ming3,4; Shi, Xiao-Shan4; Meng, Ling-Hong2,3,4; Xu, Rui4; Wang, Bin-Gui1,2,3,4
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2024-04-01 |
| 卷号 | 220页码:7 |
| 关键词 | Marine-derived fungus Mangrove plant Penicillium sumatrense Curvularin derivatives Antimicrobial and cytotoxic activities |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2024.114000 |
| 通讯作者 | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| 英文摘要 | Sumalarins D-G (1-4), four previously undescribed curvularin derivatives, along with two known related metabolites, curvularin (5) and dehydrocurvularin (6), were isolated and identified from the mangrove-derived fungus Penicillium sumatrense MA-325. Among them, sumalarin D (1) represents a unique example of curvularin derivative featuring a 5-methylfuran-2-yl-methyl group. Their structures were elucidated based on analysis of NMR and MS data as well as comparison of ECD spectra and quantum chemical calculations of NMR, and compound 1 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, 5, and 6 are active against aquatic pathogenic bacteria Vibrio alginolyticus and V. harveyi with MIC values ranging from 4 to 64 mu g/mL, while compound 6 is cytotoxic against tumor cell lines 5673, HCT 116, 786-O, and Hela with IC50 values of 3.5, 10.6, 10.9, and 14.9 mu M, respectively. |
| WOS关键词 | METABOLITES ; RHIZOSPHERE ; POLYKETIDE |
| 资助项目 | National Natural Science Foundation of China[31570356] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001178000100001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/184837]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yi-Ran,Dong, Yu-Liang,Li, Xiao-Ming,et al. Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325[J]. PHYTOCHEMISTRY,2024,220:7. |
| APA | Wang, Yi-Ran.,Dong, Yu-Liang.,Li, Xiao-Ming.,Shi, Xiao-Shan.,Meng, Ling-Hong.,...&Wang, Bin-Gui.(2024).Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325.PHYTOCHEMISTRY,220,7. |
| MLA | Wang, Yi-Ran,et al."Curvularin derivatives from the marine mangrove derived fungus Penicillium sumatrense MA-325".PHYTOCHEMISTRY 220(2024):7. |
入库方式： OAI收割
来源：海洋研究所
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