In vivo immunological activity of chitosan-derived nanoparticles
文献类型：期刊论文
| 作者 | Xu, Chaojie ; Xing, Ronge2; Liu, Song; Qin, Yukun; Li, Kecheng; Yu, Huahua; Li, Pengcheng
|
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2024-03-01 |
| 卷号 | 262页码:9 |
| 关键词 | Chitosan-derived Nanoparticles Immunity Adjuvant Vaccine |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2024.130105 |
| 通讯作者 | Xing, Ronge(xingronge@qdio.ac.cn) |
| 英文摘要 | Chitosan has been studied as an immunomodulator, but few studies have used chitosan derivatives as adjuvants alone. After a preliminary study, we found that nanoparticles prepared from chitosan derivatives had better cellular immune activity when used as an adjuvant. Therefore, animal experiments were conducted to further investigate the performance and mechanism of these nanoparticles as immune adjuvants. We injected mice with the chitosan nanoparticle vaccine and measured the expression levels of immunoglobulins, immune factors, and immune genes in tissues and tissue sections. The results showed that C236-HACC-OVA (C2,3,6-chitosan sulfatechitosan quaternary ammonium salt-ovalbumin) and NO-HACC-OVA (NO-carboxymethyl chitosan-chitosan quaternary ammonium salt-ovalbumin) nanoparticles can significantly improve the secretion of the immune factors IL -6, TNF, and IL-1 beta. The level of IgG1 was highly significant after administering both nanoparticles, but IgG2 was not significant in mice. Three immune factors (IL -4, IL -6, and IL -17) were secreted at high levels in mouse serum at a nanoparticle dose of 0.3 mg/mouse. These nanoparticles also have high safety in the liver, kidney, and spleen of mice. This study proves the possibility of using chitosan derivative nanoparticles as vaccine adjuvants. These data further indicate that chitosan derivative nanoparticles have potential for use as vaccine adjuvants and demonstrate that polysaccharides have a unique position in green vaccine research. |
| WOS关键词 | IMMUNE-RESPONSES ; CARBOXYMETHYL CHITOSAN ; VACCINE ; ADJUVANT ; DELIVERY ; CHITIN |
| 资助项目 | Qingdao Marine Science and Technology Center[2022QNLM030003-2] ; The Key R&D Program (Major Scientific and Technological Innovation Project) of Shandong Province, China[2022CXGC020413] ; The Key R&D Program (Major Scientific and Technological Innovation Project) of Shandong Province, China[2023CXGC010412] ; Shandong Provincial Natural Science Foundation[ZR2023QD180] ; China Postdoctoral Science Foundation project[2023M733530] ; Natural Science Foundation of Shandong Province[ZR2022YQ37] ; Qingdao Postdoctoral Project ; Key R&D Program (Major Scientific and Technological Innovation Project) of Shandong Province, China[2023CXGC010412] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001187950400001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/184953]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xing, Ronge |
| 作者单位 | 1.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Chaojie,Xing, Ronge,Liu, Song,et al. In vivo immunological activity of chitosan-derived nanoparticles[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,262:9. |
| APA | Xu, Chaojie.,Xing, Ronge.,Liu, Song.,Qin, Yukun.,Li, Kecheng.,...&Li, Pengcheng.(2024).In vivo immunological activity of chitosan-derived nanoparticles.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,262,9. |
| MLA | Xu, Chaojie,et al."In vivo immunological activity of chitosan-derived nanoparticles".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 262(2024):9. |
入库方式： OAI收割
来源：海洋研究所
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