Fucoidan from the cell wall of Silvetia siliquosa with immunomodulatory effect on RAW 264.7 cells
文献类型：期刊论文
| 作者 | Geng, Lihua5,6,7,8; Zhang, Quanbin5,6,7,8; Li, Qiong4 ; Zhang, Qian3,5; Wang, Cong2; Song, Ni2; Xin, Wenyu1
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2024-05-15 |
| 卷号 | 332页码:13 |
| 关键词 | Silvetia siliquosa Fucoidan Polysaccharide Immunomodulatory activity Sulfate groups |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2024.121883 |
| 通讯作者 | Xin, Wenyu(xinwenyu1391139@163.com) |
| 英文摘要 | Silvetia siliquosa, the only species of the family Fucaceae in China, is used as a medicine food homology. Fucoidan from S. siliquosa was extracted by hot water twice thoroughly (13 % of total yield), and a purified fucoidan SSF with a molecular weight of 93 kD was obtained. Chemical composition analysis demonstrated that SSF was primarily composed of sulfate (21.68 wt%) and fucose (84 % of all neutral monosaccharides). IR, methylation analysis, NMR and ESI-MS results indicated SSF had the backbone of mainly (1 -* 3)-alpha-L-fucopyranose and minor (1 -* 4)-alpha-L-fucopyranose, with little 1,3 and 1,4 branched beta-D-Xylp and beta-D-Galp. The in vitro immunomodulatory test on RAW 264.7 cells showed that SSF could up-regulate the expression of immune related factors and proteins in a concentration-dependent manner, but the immunomodulatory effect disappeared from desulfated SSF. This research indicated that highly sulfated fucan possessed immunomodulatory effect and the importance of sulfate groups in the activity of SSF. |
| WOS关键词 | SACCHARINA-JAPONICA ; BROWN SEAWEED ; STRUCTURAL CHARACTERISTICS ; SULFATED POLYSACCHARIDES ; EXTRACTION ; HETEROPOLYSACCHARIDE ; FUCOSTEROL ; ALGAE |
| 资助项目 | National Natural Science Foundation of China[32201049] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001183973800001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/184989]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xin, Wenyu |
| 作者单位 | 1.Binzhou Med Univ, Sch Pharm, Key Lab Prescript Effect & Clin Evaluat State Adm, Yantai, Shandong, Peoples R China 2.Ocean Univ China, Sch Med & Pharm, Qingdao, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Publ Technol Serv Ctr, Qingdao, Peoples R China 4.Shandong Marine Forecast & Hazard Mitigat Serv, Qingdao, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China 6.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 7.Inst Oceanol, Chinese Acad Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 8.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Lihua,Zhang, Quanbin,Li, Qiong,et al. Fucoidan from the cell wall of Silvetia siliquosa with immunomodulatory effect on RAW 264.7 cells[J]. CARBOHYDRATE POLYMERS,2024,332:13. |
| APA | Geng, Lihua.,Zhang, Quanbin.,Li, Qiong.,Zhang, Qian.,Wang, Cong.,...&Xin, Wenyu.(2024).Fucoidan from the cell wall of Silvetia siliquosa with immunomodulatory effect on RAW 264.7 cells.CARBOHYDRATE POLYMERS,332,13. |
| MLA | Geng, Lihua,et al."Fucoidan from the cell wall of Silvetia siliquosa with immunomodulatory effect on RAW 264.7 cells".CARBOHYDRATE POLYMERS 332(2024):13. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。