Structure and function analyses of the SRC gene in Pacific white shrimp Litopenaeus vannamei
文献类型：期刊论文
| 作者 | Si, Shuqing2,3,4; Zhang, Xiaojun2,3,4; Yu, Yang2,3,4 ; Zhong, Xiaoyun2,3,4; Zhang, Xiaoxi3,4; Yuan, Jianbo2,3,4; Li, Fuhua1,2,3,4
|
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2024-04-01 |
| 卷号 | 147页码:12 |
| 关键词 | Litopenaeus vannamei SRC Gene structure and function Gene expression Growth |
| ISSN号 | 1050-4648 |
| DOI | 10.1016/j.fsi.2024.109433 |
| 通讯作者 | Zhang, Xiaojun(xjzhang@qdio.ac.cn) |
| 英文摘要 | SRC gene encodes scavenger receptor class C, a member of the scavenger receptor family, and has only been identified and investigated in invertebrates. Our previous studies have revealed that SRC is a novel candidate gene associated with body weight in Pacific white shrimp (Litopenaeus vannamei). In order to comprehend the underlying mechanism by which LvSRC affects shrimp growth, we analyzed the structure, phylogeny, expression profiles and RNA interference (RNAi) of this gene in L. vannamei. We found that LvSRC contains two CCP domains and one MAM domain, with the highest expression level in the heart and relatively low expression level in other tissues. Notably, LvSRC exhibited significantly higher expression levels in the fast-growing group among groups with different growth rates, suggesting its potential involvement as a gene contributing to the growth of L. vannamei. RNAi of LvSRC inhibited body length and body weight gain compared to the control groups. Moreover, through RNA-seq analysis, we identified 598 differentially expressed genes (DEGs), including genes associated with growth, immunity, protein processing and modification, signal transduction, lipid synthesis and metabolism. Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed significant changes in the signaling pathways related to growth, lipid metabolism and immune response, suggesting that LvSRC exhibits the potential to participate in diverse physiological processes and immune regulation. These findings deepen our understanding of the structure and function of the SRC in shrimp and lay the foundation for further research into the regulatory mechanism of LvSRC. Additionally, they provide potential applications in shrimp genetics and breeding. |
| WOS关键词 | SCAVENGER RECEPTORS ; MARSUPENAEUS-JAPONICUS ; INNATE IMMUNITY ; PROTEIN ; EXPRESSION ; PHAGOCYTOSIS ; INNEXIN-2 ; SEQUENCE ; GROWTH ; DOMAIN |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24030105] ; National Natural Sciences Foundation of China[32273102] ; National Natural Sciences Foundation of China[31972782] ; National Key R & D Program of China[2022YFF1000304] ; Agriculture Research System -48 of China[CARS -48] ; Taishan Scholars Program ; Oceanographic Data Center, IOCAS |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001187940300001 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/184998]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Zhang, Xiaojun |
| 作者单位 | 1.Chinese Acad Sci, Innovat Seed Design, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan 430072, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Si, Shuqing,Zhang, Xiaojun,Yu, Yang,et al. Structure and function analyses of the SRC gene in Pacific white shrimp Litopenaeus vannamei[J]. FISH & SHELLFISH IMMUNOLOGY,2024,147:12. |
| APA | Si, Shuqing.,Zhang, Xiaojun.,Yu, Yang.,Zhong, Xiaoyun.,Zhang, Xiaoxi.,...&Li, Fuhua.(2024).Structure and function analyses of the SRC gene in Pacific white shrimp Litopenaeus vannamei.FISH & SHELLFISH IMMUNOLOGY,147,12. |
| MLA | Si, Shuqing,et al."Structure and function analyses of the SRC gene in Pacific white shrimp Litopenaeus vannamei".FISH & SHELLFISH IMMUNOLOGY 147(2024):12. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。