Low molecular weight fucoidan LF2 improves the immunosuppressive tumor microenvironment and enhances the anti-pancreatic cancer activity of oxaliplatin
文献类型：期刊论文
| 作者 | Deng, Zhenzhen1,3,4,5; Qishan, Suo1,3,4,5 ; Zhang, Quanbin1,3,4,5; Wang, Jing3,4,5; Yue, Yang3,4,5; Geng, Lihua3,4,5; Wu, Ning1,2,4,5
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| 刊名 | BIOMEDICINE & PHARMACOTHERAPY
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| 出版日期 | 2024-04-01 |
| 卷号 | 173页码:10 |
| 关键词 | Fucoidan Tumor microenvironment Macrophages Oxaliplatin |
| ISSN号 | 0753-3322 |
| DOI | 10.1016/j.biopha.2024.116360 |
| 通讯作者 | Wu, Ning(wuning@qdio.ac.cn) |
| 英文摘要 | Chemotherapy remains the cornerstone of pancreatic cancer treatment. However, the dense interstitial and immunosuppressive microenvironment frequently render the ineffective anti -tumor activity of chemotherapeutic agents. Macrophages play a key role in the tumor immunomodulation. In this study, we found that low molecular weight of fucoidan (LF2) directly regulated the differentiation of mononuclear macrophages into the CD86+ M1 phenotype. LF2 significantly upregulated the expressions of M1 macrophage -specific cytokines, including iNOS, IL -6, TNF alpha and IL -12. LF2 modulated macrophage phenotypic transformation through activation of TLR4-NF kappa B pathway. Furthermore, we observed that LF2 enhanced the pro-apoptotic activity of oxaliplatin (OXA) in vitro by converting macrophages to a tumoricidal M1 phenotype. Meanwhile, LF2 increased intratumoral M1 macrophage infiltration and ameliorated the immunosuppressed tumor microenvironment, which in turn enhanced the anti -pancreatic ductal adenocarcinoma (PDAC) activity of OXA in vivo. Taken together, our results suggested that LF2 could act as a TLR4 agonist targeting macrophages and has a synergistic effect against PDAC when combined with OXA. |
| WOS关键词 | MACROPHAGES ; M1 ; CELLS |
| 资助项目 | National Natural Science Fundation of China[42176137] ; National Natural Science Fundation of China[81872906] ; National Key R & D Program of China[2022YFD2401203] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001197629800001 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/185052]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wu, Ning |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Biol Prod, Qingdao, Peoples R China 3.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Zhenzhen,Qishan, Suo,Zhang, Quanbin,et al. Low molecular weight fucoidan LF2 improves the immunosuppressive tumor microenvironment and enhances the anti-pancreatic cancer activity of oxaliplatin[J]. BIOMEDICINE & PHARMACOTHERAPY,2024,173:10. |
| APA | Deng, Zhenzhen.,Qishan, Suo.,Zhang, Quanbin.,Wang, Jing.,Yue, Yang.,...&Wu, Ning.(2024).Low molecular weight fucoidan LF2 improves the immunosuppressive tumor microenvironment and enhances the anti-pancreatic cancer activity of oxaliplatin.BIOMEDICINE & PHARMACOTHERAPY,173,10. |
| MLA | Deng, Zhenzhen,et al."Low molecular weight fucoidan LF2 improves the immunosuppressive tumor microenvironment and enhances the anti-pancreatic cancer activity of oxaliplatin".BIOMEDICINE & PHARMACOTHERAPY 173(2024):10. |
入库方式： OAI收割
来源：海洋研究所
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