Dietary steroids promote body weight growth and induce gametogenesis by increasing the expressions of genes related to cell proliferation of sea cucumber (Apostichopus japonicus)
文献类型：期刊论文
| 作者 | Liang, Wen-ke3,4,5,6,7; Zhang, Li-bin1,3,4,5,6; Xu, Jia-lei2 |
| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
 |
| 出版日期 | 2024-03-01 |
| 卷号 | 49页码:11 |
| 关键词 | Steroids Testosterone Cholesterol Apostichopus japonicus RNA -sequencing |
| ISSN号 | 1744-117X |
| DOI | 10.1016/j.cbd.2024.101191 |
| 通讯作者 | Zhang, Li-bin(zhanglibin@qdio.ac.cn) |
| 英文摘要 | Steroids play a vital role in animal survival, promoting growth and development when administered appropriate concentration exogenously. However, it remains unclear whether steroids can induce gonadal development and the underlying mechanism. This study assessed sea cucumber weights post-culturing, employing paraffin sections and RNA sequencing (RNA-seq) to explore gonadal changes and gene expression in response to exogenous steroid addition. Testosterone and cholesterol, dissolved in absolute ethanol, were incorporated into sea cucumber diets. After 30 days, testosterone and cholesterol significantly increased sea cucumber weights, with the total weight of experimental groups surpassing the control. The testosterone-fed group exhibited significantly higher eviscerated weight than the control group. In addition, dietary steroids influenced gonad morphology and upregulated genes related to cell proliferation,such as RPL35, PC, eLF-1, MPC2, ADCY10 and CYP2C18. Thees upregulated differentially expressed genes were significantly enriched in the organic system, metabolism, genetic information and environmental information categories. These findings imply that steroids may contribute to the growth and the process of genetic information translation and protein synthesis essential for gonadal development and gametogenesis. |
| WOS关键词 | CHOLESTEROL REQUIREMENT ; CYTOCHROME-P450 GENES ; REPRODUCTIVE-BIOLOGY ; TELEOST FISHES ; JAPANESE EEL ; TESTOSTERONE ; HORMONE ; IDENTIFICATION ; METABOLISM ; PRAWN |
| 资助项目 | National Natural Science Foundation of China (NSFC-FDCT project)[42061160365] ; Natural science Foundation of Shandong Province[ZR2023MD090] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:001170350200001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/184902]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Zhang, Li-bin |
| 作者单位 | 1.Inst Oceanol, Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Zhongke Tonhe Shandong Marine Technol Co Ltd, Dongying 257200, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 6.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 7.Qingdao Agr Univ, Coll Life Sci, Qingdao 266109, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Wen-ke,Zhang, Li-bin,Xu, Jia-lei. Dietary steroids promote body weight growth and induce gametogenesis by increasing the expressions of genes related to cell proliferation of sea cucumber (Apostichopus japonicus)[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,2024,49:11. |
| APA | Liang, Wen-ke,Zhang, Li-bin,&Xu, Jia-lei.(2024).Dietary steroids promote body weight growth and induce gametogenesis by increasing the expressions of genes related to cell proliferation of sea cucumber (Apostichopus japonicus).COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,49,11. |
| MLA | Liang, Wen-ke,et al."Dietary steroids promote body weight growth and induce gametogenesis by increasing the expressions of genes related to cell proliferation of sea cucumber (Apostichopus japonicus)".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 49(2024):11. |
入库方式： OAI收割
来源：海洋研究所
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