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Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis

文献类型：期刊论文

作者Huo, Da2,3,4,5; Liu, Shilin2,3,4,5; Zhang, Libin2,3,4,5; Yang, Hongsheng2,3,4,5; Sun, Lina1,2,3,4,5
刊名MOLECULAR ECOLOGY
出版日期2024-04-16
页码19
关键词Apostichopus japonicus ribosome profiling RNA-seq transcriptional regulation translational efficiency translational regulation
ISSN号0962-1083
DOI10.1111/mec.17352
通讯作者Sun, Lina(sunlina@qdio.ac.cn)
英文摘要Low dissolved oxygen (LO) conditions represent a major environmental challenge to marine life, especially benthic animals. For these organisms, drastic declines in oxygen availability (hypoxic events) can trigger mass mortality events and thus, act as agents of selection influencing the evolution of adaptations. In sea cucumbers, one of the most successful groups of benthic invertebrates, the exposure to hypoxic conditions triggers adaptive adjustments in metabolic rates and behaviour. It is unclear, however, how these adaptive responses are regulated and the genetic mechanisms underpinning them. Here, we addressed this knowledge gap by assessing the genetic regulation (transcription and translation) of hypoxia exposure in the sea cucumber Apostichopus japonicus. Transcriptional and translational gene expression profiles under short- and long-term exposure to low oxygen conditions are tightly associated with extracellular matrix (ECM)-receptor interaction in which laminin and collagen likely have important functions. Finding revealed that genes with a high translational efficiency (TE) had a relatively short upstream open reading frame (uORF) and a high uORF normalized minimal free energy, suggesting that sea cucumbers may respond to hypoxic stress via altered TE. These results provide valuable insights into the regulatory mechanisms that confer adaptive capacity to holothurians to survive oxygen deficiency conditions and may also be used to inform the development of strategies for mitigating the harmful effects of hypoxia on other marine invertebrates facing similar challenges.
WOS关键词CUCUMBER APOSTICHOPUS-JAPONICUS ; RIBOSOME PROFILING REVEALS ; GENOME-WIDE ANALYSIS ; GENE-EXPRESSION ; BASEMENT-MEMBRANES ; RESPIRATORY TREE ; IN-VIVO ; LAMININ ; COLLAGEN ; LANDSCAPE
资助项目National Natural Science Foundation of China ; Shandong Provincial Natural Science Foundation[ZR2021QD013] ; National Key R&D Program of China[2022YFF0802202] ; Postdoctoral Innovative Talents Support Program of Shandong Province[SDBX2020006] ; Special Research Assistant Project of Chinese Academy of Sciences ; Taishan Scholars Program (Youth Taishan Scholars)[tsqn202306287] ; [42261160378] ; [42106106]
WOS研究方向Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology
语种英语
WOS记录号WOS:001203102200001
出版者WILEY
源URL[http://ir.qdio.ac.cn/handle/337002/185130]  
专题海洋研究所_海洋生态与环境科学重点实验室
通讯作者Sun, Lina
作者单位1.Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
2.Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Qingdao Marine Sci & Technol Ctr, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
推荐引用方式
GB/T 7714		 Huo, Da,Liu, Shilin,Zhang, Libin,et al. Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis[J]. MOLECULAR ECOLOGY,2024:19.
APA Huo, Da,Liu, Shilin,Zhang, Libin,Yang, Hongsheng,&Sun, Lina.(2024).Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis.MOLECULAR ECOLOGY,19.
MLA Huo, Da,et al."Importance of the ECM-receptor interaction for adaptive response to hypoxia based on integrated transcription and translation analysis".MOLECULAR ECOLOGY (2024):19.

入库方式： OAI收割

来源：海洋研究所

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