Curcumin-polydopamine nanoparticles alleviate ferroptosis by iron chelation and inhibition of oxidative stress damage
文献类型：期刊论文
| 作者 | Lei, Li3,4; Yuan, Jiali4; Yang, Qingqing2; Tu, Qiuxia4; Yu, Haijun1 ; Chu, Liangzhao3; Tang, Lei2; Zhang, Chunlin4
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| 刊名 | RSC ADVANCES
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| 出版日期 | 2024-05-02 |
| 卷号 | 14期号:21页码:14934-14941 |
| DOI | 10.1039/d4ra02336f |
| 通讯作者 | Chu, Liangzhao() ; Tang, Lei() ; Zhang, Chunlin() |
| 英文摘要 | Ferroptosis, characterized by elevated iron levels and lipid peroxidation (LPO), is a recently identified regulatory mechanism of cell death. Its substantial involvement in ischemic tissue injury, neurodegenerative disorders, and cancer positions ferroptosis inhibition as a promising strategy for managing these diverse diseases. In this study, we introduce curcumin-polydopamine nanoparticles (Cur-PDA NPs) as an innovative ferroptosis inhibitor. Cur-PDA NPs demonstrate remarkable efficacy in chelating both Fe2+ and Fe3+in vitro along with scavenging free radicals. Cur-PDA NPs were found to efficiently mitigate reactive oxygen species, reduce Fe2+ accumulation, suppress LPO, and rejuvenate mitochondrial function in PC12 cells. Thus, these NPs can act as potent therapeutic agents against ferroptosis, primarily via iron chelation and reduction of oxidative stress. A Cur-PDA NP based nanoregulator was developed for targeting ferroptosis to mitigate neuron degeneration by regulating iron and ROS homeostasis, suppressing lipid peroxidation and oxidative stress, and improving mitochondrial function. |
| WOS关键词 | CELL-DEATH |
| 资助项目 | National Natural Science Foundation of China[82160234] ; National Natural Science Foundation of China[32360241] ; National Natural Science Foundation of China[ZK[2023]293] ; Guizhou Provincial Science and Technology Projects[RN21045] ; Elexible Talents Program of Guizhou Medical University[QZYY-2024-010] ; Science and technology research project of traditional Chinese medicine and ethnic medicine of Guizhou Province Administration of Traditional Chinese Medicine[21NSFCP24] ; Cultivation program of Guizhou Medical University[202210660044] ; Cultivation program of Guizhou Medical University[S202310660032] ; Cultivation program of Guizhou Medical University[S202310660039] ; National College Students Innovation and Entrepreneurship Training Program ; Molecular Medicine Engineering Research Center of Guizhou Medical University ; Key Laboratory of Pathogenesis and Drug Research of Common Chronic Diseases in Guizhou Province |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001215104000001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310885]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chu, Liangzhao; Tang, Lei; Zhang, Chunlin |
| 作者单位 | 1.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Guizhou Med Univ, Coll Pharm, Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, Guiyang 550025, Peoples R China 3.Guizhou Med Univ, Dept Neurosurg, Affiliated Hosp, Guiyang, Guizhou, Peoples R China 4.Guizhou Med Univ, Engn Res Ctr Mol Med, Sch Basic Med Sci, Guiyang 550025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Li,Yuan, Jiali,Yang, Qingqing,et al. Curcumin-polydopamine nanoparticles alleviate ferroptosis by iron chelation and inhibition of oxidative stress damage[J]. RSC ADVANCES,2024,14(21):14934-14941. |
| APA | Lei, Li.,Yuan, Jiali.,Yang, Qingqing.,Tu, Qiuxia.,Yu, Haijun.,...&Zhang, Chunlin.(2024).Curcumin-polydopamine nanoparticles alleviate ferroptosis by iron chelation and inhibition of oxidative stress damage.RSC ADVANCES,14(21),14934-14941. |
| MLA | Lei, Li,et al."Curcumin-polydopamine nanoparticles alleviate ferroptosis by iron chelation and inhibition of oxidative stress damage".RSC ADVANCES 14.21(2024):14934-14941. |
入库方式： OAI收割
来源：上海药物研究所
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