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Colchicine-loaded transethosomes enhances transdermal permeability and therapeutic effects of acute gouty arthritis via vesicle extrusion and lipid perturbation

文献类型：期刊论文

作者Zi, Miaomiao4; Ke, Jiming4; Jiang, Suping4; Cui, Xinge4; Zhang, Jing4; Yuan, Shujie4; Huang, Shan4; Wang, Jie4; Liu, Huanhuan3; Zhang, Jiwen2
刊名COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
出版日期2024-04-20
卷号687页码:9
关键词Transethosomes Colchicine Transdermal penetration mechanism Acute gout
ISSN号0927-7757
DOI10.1016/j.colsurfa.2024.133582
通讯作者Liu, Huanhuan(huanhuanliu2016@ahtcm.edu.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) ; Peng, Can(pengcan@ahtcm.edu.cn)
英文摘要Colchicine (COL) is the primary medication for treating an acute gout attack, however, it has a narrow therapeutic index and can cause mild to severe gastrointestinal side effects when administered orally. To address this, transethosomes (TEs) were developed as a transdermal drug delivery vehicle for COL in order to promote permeability. Studies have shown that TEs can disrupt the multilamellar and organized lipid domains of the skin, alter the structure of keratin, and increase the fluidity of the stratum corneum (SC), which facilitates the penetration of COL into the deeper layers of the skin. Additionally, ethanol has been found to play a role in the infiltration process, but is not the sole driving force. Results have demonstrated that COL-TEs have higher transdermal efficiency, increased drug permeability, longer skin retention time, and better biocompatibility than the COL water solution and the 40% ethanol COL -solution. Furthermore, the drug was found to effectively reduce inflammatory cytokine levels, thus providing the expected therapeutic effects.
WOS关键词SKIN PENETRATION ; IN-VITRO ; EX-VIVO ; DELIVERY ; HYPERURICEMIA ; PREVALENCE ; PERMEATION ; MECHANISM ; DRUGS
资助项目Research Funds of Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM[2023CXMMTCM006] ; Distinguished young scholars' science project for universities in Anhui province[2023AH020035] ; Major Special Science and Technology of Anhui Province[202103a07020001] ; Anhui Universities Collaborative Innovation Project[GXXT-2022-075] ; Anhui Universities Collaborative Innovation Project[GXXT-2022-084] ; Anhui Universities Collaborative Innovation Project[GXXT-2020-025]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001209201700001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/310971]  
专题中国科学院上海药物研究所
通讯作者Liu, Huanhuan; Zhang, Jiwen; Peng, Can
作者单位1.Anhui Univ Chinese Med, Anhui Prov Key Lab Pharmaceut Preparat Technol &, Anhui Prov Key Lab Chinese Med Formula,Inst TCM R, Sch Pharm,Anhui Acad Chinese Med,MOE Anhui Joint, Hefei 230012, Anhui, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China
3.Anhui Univ Chinese Med, Anhui Prov Key Lab Pharmaceut Preparat Technol &, Anhui Acad Chinese Med,Inst Pharmaceut,Sch Pharm, Engn Technol Res Ctr Modernized Pharmaceut,Anhui, Hefei 230012, Anhui, Peoples R China
4.Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Zi, Miaomiao,Ke, Jiming,Jiang, Suping,et al. Colchicine-loaded transethosomes enhances transdermal permeability and therapeutic effects of acute gouty arthritis via vesicle extrusion and lipid perturbation[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2024,687:9.
APA Zi, Miaomiao.,Ke, Jiming.,Jiang, Suping.,Cui, Xinge.,Zhang, Jing.,...&Peng, Can.(2024).Colchicine-loaded transethosomes enhances transdermal permeability and therapeutic effects of acute gouty arthritis via vesicle extrusion and lipid perturbation.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,687,9.
MLA Zi, Miaomiao,et al."Colchicine-loaded transethosomes enhances transdermal permeability and therapeutic effects of acute gouty arthritis via vesicle extrusion and lipid perturbation".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 687(2024):9.

入库方式： OAI收割

来源：上海药物研究所

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