Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis
文献类型：期刊论文
| 作者 | Liu, Jiao5; Liu, Zi-Yi3,4; Fu, Yan3; Gu, Yu-Cheng2; Li, Song-Wei5; Zhang, Hai-Yan3,4 ; Guo, Yue-Wei1,5
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2024-04-30 |
| 页码 | 5 |
| 关键词 | Sponge Spongia officinalis Chemical investigation Absolute configuration Anti-inflammatory activity |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202400519 |
| 通讯作者 | Li, Song-Wei(simmswli@163.com) ; Zhang, Hai-Yan(hzhang@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | One new highly degraded steroid, namely 21-nor-4-ene-chaxine A (1) furnishing a 5/6/5-tricyclic, along with one known related analogue (2), were isolated from the South China Sea sponge Spongia officinalis. Their structures including absolute configurations were established by extensive spectroscopic data analysis, TDDFT-ECD calculation, and comparison with the spectral data previously reported in the literature. Compound 1 represent the new member of incisterols family with a highly degradation in ring B. In vitro bioassays revealed compound 2 exhibited significant anti-microglial inflammatory effect on lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells. |
| WOS关键词 | DERIVATIVES |
| 资助项目 | National Key Research and Development Program of China ; National Science Foundation of China[81991521] ; [2022YFC2804100] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001209718600001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/310977]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Song-Wei; Zhang, Hai-Yan; Guo, Yue-Wei |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berkshire, England 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 4.Nanchang Univ, Sch Pharmaceut Sci, Nanchang 330006, Peoples R China 5.Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jiao,Liu, Zi-Yi,Fu, Yan,et al. Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis[J]. CHEMISTRY & BIODIVERSITY,2024:5. |
| APA | Liu, Jiao.,Liu, Zi-Yi.,Fu, Yan.,Gu, Yu-Cheng.,Li, Song-Wei.,...&Guo, Yue-Wei.(2024).Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis.CHEMISTRY & BIODIVERSITY,5. |
| MLA | Liu, Jiao,et al."Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis".CHEMISTRY & BIODIVERSITY (2024):5. |
入库方式： OAI收割
来源：上海药物研究所
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