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Macrolide sesquiterpene pyridine alkaloids from Celastrus monospermus and evaluation of their immunosuppressive and anti-osteoclastogenesis activities

文献类型：期刊论文

作者Ning, Ruonan4,5,6; Zhao, Jie4,5; Chen, Li3,4; Mu, Hongyan4,5; Chen, Zhongxian4,5; Yang, Kai6; Xu, Xing6; Litifu, Dilinaer3,4; Zuo, Jianping3,4; He, Shijun2
刊名BIOORGANIC CHEMISTRY
出版日期2024-04-01
卷号145页码:14
关键词Macrolide sesquiterpene pyridine alkaloid Celastrus monospermus Roxb Immunosuppressive Anti-osteoclastogenesis
ISSN号0045-2068
DOI10.1016/j.bioorg.2024.107246
通讯作者He, Shijun(heshijun@shutcm.edu.cn) ; Jiang, Min(jiangm263@163.com) ; Zhao, Weimin(wmzhao@simm.ac.cn)
英文摘要Phytochemical investigation of the stems of Celastrus monospermus Roxb enabled isolation and identification of fifteen new macrolide sesquiterpene pyridine alkaloids (1-15) along with five known analogues. Their structures were elucidated by comprehensive spectroscopic analysis (NMR, HRESIMS, IR, UV), chemical hydrolysis, and single crystal X-ray diffraction analysis. Bioassay of the abundant isolates revealed that seven compounds inhibited the proliferation of B lymphocytes with IC50 values ranging between 1.4 and 19.9 mu M. Among them, celasmondine C (3) could significantly promote the apoptosis of activated B lymphocyte, especially late-stage apoptosis. Besides, compounds 3, 16, and 20 exhibited potent suppression of osteoclast formation at a concentration of 1.0 mu M. This investigation enriched the chemical diversity of macrolide sesquiterpene pyridine alkaloids, and supported evidence for the development of new immunosuppressive and anti-osteoclastogenesis agents.
资助项目Shanghai Key Laboratory of Tuberculosis[2022-KF-07] ; National Natural Science Foundation of China[22277076] ; National Natural Science Foundation of China[82070902] ; State Key Laboratory of Drug Research[SKLDR-2023-KF-06] ; State Key Laboratory of Drug Research[SKLDR-2023-KF-02]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001209114700001
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/310986]  
专题新药研究国家重点实验室
通讯作者He, Shijun; Jiang, Min; Zhao, Weimin
作者单位1.Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China
6.Shanghai Jiao Tong Univ, Shanghai Inst Traumatol & Orthopaed, Shanghai Key Lab Prevent & Treatment Bone & Joint, Ruijin Hosp,Sch Med,Dept Orthopaed, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
推荐引用方式
GB/T 7714		 Ning, Ruonan,Zhao, Jie,Chen, Li,et al. Macrolide sesquiterpene pyridine alkaloids from Celastrus monospermus and evaluation of their immunosuppressive and anti-osteoclastogenesis activities[J]. BIOORGANIC CHEMISTRY,2024,145:14.
APA Ning, Ruonan.,Zhao, Jie.,Chen, Li.,Mu, Hongyan.,Chen, Zhongxian.,...&Zhao, Weimin.(2024).Macrolide sesquiterpene pyridine alkaloids from Celastrus monospermus and evaluation of their immunosuppressive and anti-osteoclastogenesis activities.BIOORGANIC CHEMISTRY,145,14.
MLA Ning, Ruonan,et al."Macrolide sesquiterpene pyridine alkaloids from Celastrus monospermus and evaluation of their immunosuppressive and anti-osteoclastogenesis activities".BIOORGANIC CHEMISTRY 145(2024):14.

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来源：上海药物研究所

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