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Cross-ancestry genome-wide association studies of brain imaging phenotypes

文献类型：期刊论文

作者Fu, Jilian45,46; Zhang, Quan45; Wang, Jianhua43; Wang, Meiyun40,41,42; Zhang, Bing39; Zhu, Wenzhen38; Qiu, Shijun37; Geng, Zuojun36; Cui, Guangbin34,35; Yu, Yongqiang33
刊名NATURE GENETICS
出版日期2024-05-29
页码31
ISSN号1061-4036
DOI10.1038/s41588-024-01766-y
通讯作者Cheng, Jingliang(cjr.chjl@vip.163.com) ; Li, Mulin Jun(mulin@tmu.edu.cn) ; Yu, Chunshui(chunshuiyu@tmu.edu.cn)
英文摘要Genome-wide association studies of brain imaging phenotypes are mainly performed in European populations, but other populations are severely under-represented. Here, we conducted Chinese-alone and cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in 7,058 Chinese Han and 33,224 white British participants. We identified 38 new associations in Chinese-alone analyses and 486 additional new associations in cross-ancestry meta-analyses at P < 1.46 x 10(-11) for discovery and P < 0.05 for replication. We pooled significant autosomal associations identified by single- or cross-ancestry analyses into 6,443 independent associations, which showed uneven distribution in the genome and the phenotype subgroups. We further divided them into 44 associations with different effect sizes and 3,557 associations with similar effect sizes between ancestries. Loci of these associations were shared with 15 brain-related non-imaging traits including cognition and neuropsychiatric disorders. Our results provide a valuable catalog of genetic associations for brain imaging phenotypes in more diverse populations.
收录类别SCI
WOS关键词HERITABILITY ; VARIANTS
资助项目National Natural Science Foundation of China (National Science Foundation of China)[2018YFC1314300] ; National Key Research and Development Program of China[82030053] ; National Key Research and Development Program of China[81425013] ; National Natural Science Foundation of China ; Genetics of Personality Consortium ; International Multiple Sclerosis Genetics Consortium ; METASTROKE collaboration ; Social Science Genetic Association Consortium
WOS研究方向Genetics & Heredity
语种英语
WOS记录号WOS:001235162200001
出版者NATURE PORTFOLIO
资助机构National Natural Science Foundation of China (National Science Foundation of China) ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Genetics of Personality Consortium ; International Multiple Sclerosis Genetics Consortium ; METASTROKE collaboration ; Social Science Genetic Association Consortium
源URL[http://ir.psych.ac.cn/handle/311026/47920]  
专题心理研究所_认知与发展心理学研究室
通讯作者Cheng, Jingliang; Li, Mulin Jun; Yu, Chunshui
作者单位1.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai, Peoples R China
2.Nanjing Univ, Jinling Hosp, Affiliated Hosp, Med Sch, Nanjing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
4.Beijing Normal Univ, McGovern Inst Brain Res, Dev Populat Neurosci Res Ctr, IDG, Beijing, Peoples R China
5.Xuzhou Med Univ, Dept Radiol, Affiliated Hosp, Xuzhou, Peoples R China
6.Univ Sci & Technol China, Div Life Sci & Med, Hefei, Peoples R China
7.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr MRI Res, Beijing, Peoples R China
8.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China
9.Shandong Univ, Qilu Hosp, Dept Radiol, Jinan, Peoples R China
10.Dalian Med Univ, Affiliated Hosp 1, Dept Radiol, Dalian, Peoples R China
推荐引用方式
GB/T 7714		 Fu, Jilian,Zhang, Quan,Wang, Jianhua,et al. Cross-ancestry genome-wide association studies of brain imaging phenotypes[J]. NATURE GENETICS,2024:31.
APA Fu, Jilian.,Zhang, Quan.,Wang, Jianhua.,Wang, Meiyun.,Zhang, Bing.,...&Wu, Yue.(2024).Cross-ancestry genome-wide association studies of brain imaging phenotypes.NATURE GENETICS,31.
MLA Fu, Jilian,et al."Cross-ancestry genome-wide association studies of brain imaging phenotypes".NATURE GENETICS (2024):31.

入库方式： OAI收割

来源：心理研究所

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