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Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis

文献类型：期刊论文

作者Wang, Yaping2,3; Wang, Yufan3; Wang, Haiyan3; Ma, Liang3; Eickhoff, Simon B.6,7; Madsen, Kristoffer Hougaard1,2,8; Chu, Congying3; Fan, Lingzhong2,3,4,5
刊名CELL REPORTS
出版日期2024-02-27
卷号43期号:2页码:21
ISSN号2211-1247
DOI10.1016/j.celrep.2024.113770
通讯作者Chu, Congying(chucongying@gmail.com) ; Fan, Lingzhong(lingzhong.fan@ia.ac.cn)
英文摘要Cerebellar involvement in both motor and non -motor functions manifests in specific regions of the human cerebellum, revealing the functional heterogeneity within it. One compelling theory places the heterogeneity within the cerebellar functional hierarchy along the sensorimotor-association (SA) axis. Despite extensive neuroimaging studies, evidence for the cerebellar SA axis from different modalities and scales was lacking. Thus, we establish a significant link between the cerebellar SA axis and spatio-molecular profiles. Utilizing the gene set variation analysis, we find the intermediate biological principles the significant genes leveraged to scaffold the cerebellar SA axis. Interestingly, we find these spatio-molecular profiles notably associated with neuropsychiatric dysfunction and recent evolution. Furthermore, cerebello-cerebral interactions at genetic and functional connectivity levels mirror the cerebral cortex and cerebellum's SA axis. These findings can provide a deeper understanding of how the human cerebellar SA axis is shaped and its role in transitioning from sensorimotor to association functions.
WOS关键词PREFRONTAL CORTEX ; GENE ONTOLOGY ; DISEASE ; ATLAS ; NEUROTRANSMITTERS ; ORGANIZATION ; PROJECTIONS ; EXPRESSION ; DISORDERS ; PATTERNS
资助项目STI2030-Major Projects[2021ZD0200203] ; Natural Science Foundation of China[82072099] ; Natural Science Foundation of China[62250058] ; The 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research[1U54MH091657] ; McDonnell Center for Systems Neuroscience at Washington University
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:001188121400001
出版者CELL PRESS
资助机构STI2030-Major Projects ; Natural Science Foundation of China ; The 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research ; McDonnell Center for Systems Neuroscience at Washington University
源URL[http://ir.ia.ac.cn/handle/173211/56981]  
专题自动化研究所_脑网络组研究中心
通讯作者Chu, Congying; Fan, Lingzhong
作者单位1.Copenhagen Univ Hosp Amager & Hvidovre, Danish Res Ctr Magnet Resonance, Ctr Funct & Diagnost Imaging & Res, DK-2650 Hvidovre, Denmark
2.Univ Chinese Acad Sci, Sino Danish Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techno, Beijing 100190, Peoples R China
5.Univ Hlth & Rehabil Sci, Sch Hlth & Life Sci, Qingdao 266000, Peoples R China
6.Res Ctr Julich, Inst Neurosci & Med, INM 7 Brain & Behav, D-52425 Julich, Germany
7.Heinrich Heine Univ Dusseldorf, Inst Syst Neurosci, D-40225 Dusseldorf, Germany
8.Tech Univ Denmark, Dept Appl Math & Comp Sci, DK-2800 Lyngby, Denmark
推荐引用方式
GB/T 7714		 Wang, Yaping,Wang, Yufan,Wang, Haiyan,et al. Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis[J]. CELL REPORTS,2024,43(2):21.
APA Wang, Yaping.,Wang, Yufan.,Wang, Haiyan.,Ma, Liang.,Eickhoff, Simon B..,...&Fan, Lingzhong.(2024).Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis.CELL REPORTS,43(2),21.
MLA Wang, Yaping,et al."Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis".CELL REPORTS 43.2(2024):21.

入库方式： OAI收割

来源：自动化研究所

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