Dynamics of neuronal firing modulated by high-frequency electrical pulse stimulations at axons in rat hippocampus
文献类型：期刊论文
| 作者 | Wang,Zhaoxiang1,4; Feng,Zhouyan4; Yuan,Yue1,4; Guo,Zheshan3; Cui,Jian1; Jiang,Tianzi1,2
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| 刊名 | Journal of Neural Engineering
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| 出版日期 | 2024-04-01 |
| 卷号 | 21期号:2 |
| 关键词 | high-frequency stimulation unit spike fractal long-range temporal correlations Fano factor Hurst exponent |
| ISSN号 | 1741-2560 |
| DOI | 10.1088/1741-2552/ad37da |
| 通讯作者 | Feng,Zhouyan() |
| 英文摘要 | Abstract Objective. The development of electrical pulse stimulations in brain, including deep brain stimulation, is promising for treating various brain diseases. However, the mechanisms of brain stimulations are not yet fully understood. Previous studies have shown that the commonly used high-frequency stimulation (HFS) can increase the firing of neurons and modulate the pattern of neuronal firing. Because the generation of neuronal firing in brain is a nonlinear process, investigating the characteristics of nonlinear dynamics induced by HFS could be helpful to reveal more mechanisms of brain stimulations. The aim of present study is to investigate the fractal properties in the neuronal firing generated by HFS. Approach. HFS pulse sequences with a constant frequency 100 Hz were applied in the afferent fiber tracts of rat hippocampal CA1 region. Unit spikes of both the pyramidal cells and the interneurons in the downstream area of stimulations were recorded. Two fractal indexes—the Fano factor and Hurst exponent were calculated to evaluate the changes of long-range temporal correlations (LRTCs), a typical characteristic of fractal process, in spike sequences of neuronal firing. Main results. Neuronal firing at both baseline and during HFS exhibited LRTCs over multiple time scales. In addition, the LRTCs significantly increased during HFS, which was confirmed by simulation data of both randomly shuffled sequences and surrogate sequences. Conclusion. The purely periodic stimulation of HFS pulses, a non-fractal process without LRTCs, can increase rather than decrease the LRTCs in neuronal firing. Significance. The finding provides new nonlinear mechanisms of brain stimulation and suggests that LRTCs could be a new biomarker to evaluate the nonlinear effects of HFS. |
| 语种 | 英语 |
| WOS记录号 | IOP:JNE_21_2_026025 |
| 出版者 | IOP Publishing |
| 源URL | [http://ir.ia.ac.cn/handle/173211/57020]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Feng,Zhouyan |
| 作者单位 | 1.Zhejiang Lab, Hangzhou, People’s Republic of China 2.Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, People’s Republic of China 3.Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, Hainan, People’s Republic of China 4.Key Lab of Biomedical Engineering for Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Wang,Zhaoxiang,Feng,Zhouyan,Yuan,Yue,et al. Dynamics of neuronal firing modulated by high-frequency electrical pulse stimulations at axons in rat hippocampus[J]. Journal of Neural Engineering,2024,21(2). |
| APA | Wang,Zhaoxiang,Feng,Zhouyan,Yuan,Yue,Guo,Zheshan,Cui,Jian,&Jiang,Tianzi.(2024).Dynamics of neuronal firing modulated by high-frequency electrical pulse stimulations at axons in rat hippocampus.Journal of Neural Engineering,21(2). |
| MLA | Wang,Zhaoxiang,et al."Dynamics of neuronal firing modulated by high-frequency electrical pulse stimulations at axons in rat hippocampus".Journal of Neural Engineering 21.2(2024). |
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来源：自动化研究所
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