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Exploring the Structural Plasticity Mechanism of Corticospinal Tract during Stroke Rehabilitation Based Automated Fiber Quantification Tractography

文献类型：期刊论文

作者Zhang, Haojie6,7,8; Zhao, Jun5,8; Fan, Lingzhong2,3,4; Wu, Xia2,3,4; Li, Fang5,8; Liu, Jingya1,8; Bai, Chen6,7,8; Li, Xingzhu6,7,8; Li, Bingjie5,8; Zhang, Tong6,7,8
刊名NEUROREHABILITATION AND NEURAL REPAIR
出版日期2024-04-27
页码12
关键词automated fiber quantification corticospinal tract MRI rehabilitation stroke structural plasticity
ISSN号1545-9683
DOI10.1177/15459683241249115
通讯作者Zhang, Tong(tommzhang@163.com)
英文摘要Background Corticospinal tract (CST) is the principal motor pathway; we aim to explore the structural plasticity mechanism in CST during stroke rehabilitation.Methods A total of 25 patients underwent diffusion tensor imaging before rehabilitation (T1), 1-month post-rehabilitation (T2), 2 months post-rehabilitation (T3), and 1-year post-discharge (T4). The CST was segmented, and fractional anisotropy (FA), axial diffusion (AD), mean diffusivity (MD), and radial diffusivity (RD) were determined using automated fiber quantification tractography. Baseline level of laterality index (LI) and motor function for correlation analysis.Results The FA values of all segments in the ipsilesional CST (IL-CST) were lower compared with normal CST. Repeated measures analysis of variance showed time-related effects on FA, AD, and MD of the IL-CST, and there were similar dynamic trends in these 3 parameters. At T1, FA, AD, and MD values of the mid-upper segments of IL-CST (around the core lesions) were the lowest; at T2 and T3, values for the mid-lower segments were lower than those at T1, while the values for the mid-upper segments gradually increased; at T4, the values for almost entire IL-CST were higher than before. The highest LI was observed at T2, with a predominance in contralesional CST. The LIs for the FA and AD at T1 were positively correlated with the change rate of motor function.Conclusions IL-CST showed aggravation followed by improvement from around the lesion to the distal end. Balance of interhemispheric CST may be closely related to motor function, and LIs for FA and AD may have predictive value for mild-to-moderate stroke rehabilitation. Clinical Trial Registration. URL: http://www.chictr.org.cn; Unique Identifier: ChiCTR1800019474.
WOS关键词DIFFUSION ; DEGENERATION ; RECOVERY
资助项目The National Key Research and Development Program of China[2020YFC2007604] ; Fundamental Research Funds for Central Public Welfare Research Institutes[2018CZ-2] ; National Natural Science Foundation of China[61873135]
WOS研究方向Neurosciences & Neurology ; Rehabilitation
语种英语
WOS记录号WOS:001208784000001
出版者SAGE PUBLICATIONS INC
资助机构The National Key Research and Development Program of China ; Fundamental Research Funds for Central Public Welfare Research Institutes ; National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/57029]  
专题自动化研究所_脑网络组研究中心
通讯作者Zhang, Tong
作者单位1.China Rehabil Res Ctr, Dept Occupat Therapy, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
5.China Rehabil Res Ctr, Dept Neurol, Beijing, Peoples R China
6.China Rehabil Res Ctr, Ctr Neurol Rehabil, Beijing, Peoples R China
7.China Rehabil Sci Inst, Beijing, Peoples R China
8.Capital Med Univ, Sch Rehabil Med, 10 North Rd, Beijing 100068, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Haojie,Zhao, Jun,Fan, Lingzhong,et al. Exploring the Structural Plasticity Mechanism of Corticospinal Tract during Stroke Rehabilitation Based Automated Fiber Quantification Tractography[J]. NEUROREHABILITATION AND NEURAL REPAIR,2024:12.
APA Zhang, Haojie.,Zhao, Jun.,Fan, Lingzhong.,Wu, Xia.,Li, Fang.,...&Zhang, Tong.(2024).Exploring the Structural Plasticity Mechanism of Corticospinal Tract during Stroke Rehabilitation Based Automated Fiber Quantification Tractography.NEUROREHABILITATION AND NEURAL REPAIR,12.
MLA Zhang, Haojie,et al."Exploring the Structural Plasticity Mechanism of Corticospinal Tract during Stroke Rehabilitation Based Automated Fiber Quantification Tractography".NEUROREHABILITATION AND NEURAL REPAIR (2024):12.

入库方式： OAI收割

来源：自动化研究所

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