Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging
文献类型：期刊论文
| 作者 | Y. L. Chang, H. R. Chen, X. Y. Xie, Y. Wan, Q. Q. Li, F. X. Wu, R. Yang, W. Wang and X. G. Kong |
| 刊名 | Nature Communications
 |
| 出版日期 | 2023 |
| 卷号 | 14期号:1页码:9 |
| DOI | 10.1038/s41467-023-36813-5 |
| 英文摘要 | Fluorescence imaging in the near-infrared region yields high-quality images that overcome the current depth limitations. Here, the authors report a Tm3 + -based nanoprobe for NIR-IIb/c imaging, providing references to future bioimaging beyond 1700 nm. Fluorescence bioimaging based on rare-earth-doped nanocrystals (RENCs) in the shortwave infrared (SWIR, 1000-3000 nm) region has aroused intense interest due to deeper penetration depth and clarity. However, their downshifting emission rarely shows sufficient brightness beyond 1600 nm, especially in NIR-IIc. Here, we present a class of thulium (Tm) self-sensitized RENC fluorescence probes that exhibit bright downshifting luminescence at 1600-2100 nm (NIR-IIb/c) for in vivo bioimaging. An inert shell coating minimizes surface quenching and combines strong cross-relaxation, allowing LiTmF4@LiYF4 NPs to emit these intense downshifting emissions by absorbing NIR photons at 800 nm (large Stokes shift similar to 1000 nm with a absolute quantum yield of similar to 14.16%) or 1208 nm (NIR-IIin and NIR-IIout). Furthermore, doping with Er3+ for energy trapping achieves four-wavelength NIR irradiation and bright NIR-IIb/c emission. Our results show that Tm-based NPs, as NIR-IIb/c nanoprobes with high signal-to-background ratio and clarity, open new opportunities for future applications and translation into diverse fields. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.ciomp.ac.cn/handle/181722/67359]  |
| 专题 | 中国科学院长春光学精密机械与物理研究所 |
| 推荐引用方式 GB/T 7714 | Y. L. Chang, H. R. Chen, X. Y. Xie, Y. Wan, Q. Q. Li, F. X. Wu, R. Yang, W. Wang and X. G. Kong. Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging[J]. Nature Communications,2023,14(1):9. |
| APA | Y. L. Chang, H. R. Chen, X. Y. Xie, Y. Wan, Q. Q. Li, F. X. Wu, R. Yang, W. Wang and X. G. Kong.(2023).Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging.Nature Communications,14(1),9. |
| MLA | Y. L. Chang, H. R. Chen, X. Y. Xie, Y. Wan, Q. Q. Li, F. X. Wu, R. Yang, W. Wang and X. G. Kong."Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging".Nature Communications 14.1(2023):9. |
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