Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression
文献类型：期刊论文
| 作者 | Hu, Xianggang2,3; Chen, Tong2,3; Guo, Pengju1,2; Wang, Qing2,3; Ding, Aoxue2; Qin, Guoqing2; Wang, Wenqiong2; Xuan, Lijiang1,2,3
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2024-06-01 |
| 卷号 | 175页码:7 |
| 关键词 | Piper hongkongense piper Amide alkaloids Neolignans Inhibitory activities of PCSK9 expression |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2024.105951 |
| 通讯作者 | Wang, Wenqiong(wenqiong1019@simm.ac.cn) ; Xuan, Lijiang(ljxuan@simm.ac.cn) |
| 英文摘要 | Four undescribed amide alkaloids hongkongensines A -C and 1-(1-oxo-6-hydroxy-2 E ,4 E -dodecadienyl)-piperi- dine, five known amide alkaloids, and three known neolignans were isolated from the aerial part of Piper hongkongense . The planar structures of these compounds were determined by detailed analyses of HR-ESI-MS and NMR data. The absolute configurations of hongkongensines A -C were elucidated by single-crystal X-ray diffraction analysis and ECD calculations. Moreover, the inhibitory activities of PCSK9 expression in vitro for all compounds were assessed by PCSK9 AlphaLISA screening. Kadsurenone ( 10 ) displayed a significant inhibitory activity at 5 mu M with an inhibition rate of 51.98%, compared with 55.55% of berberine (BBR 5 mu M). |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; National Natural Science Foundation of China[82373746] ; Shanghai Municipal Science and Technology Major Project[TM202301L001] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001227309200001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311069]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wenqiong; Xuan, Lijiang |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xianggang,Chen, Tong,Guo, Pengju,et al. Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression[J]. FITOTERAPIA,2024,175:7. |
| APA | Hu, Xianggang.,Chen, Tong.,Guo, Pengju.,Wang, Qing.,Ding, Aoxue.,...&Xuan, Lijiang.(2024).Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression.FITOTERAPIA,175,7. |
| MLA | Hu, Xianggang,et al."Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression".FITOTERAPIA 175(2024):7. |
入库方式： OAI收割
来源：上海药物研究所
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