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RG-I pectin-like polysaccharide from Rosa chinensis inhibits inflammation and fibrosis associated to HMGB1/TLR4/NF- κB signaling pathway to improve non-alcoholic steatohepatitis

文献类型：期刊论文

作者Jing, Xiaoqi5; Zhou, Guangqin2,4,5; Zhu, Anming3; Jin, Can4,5; Li, Meixia5; Ding, Kan1,2,3,4,5
刊名CARBOHYDRATE POLYMERS
出版日期2024-08-01
卷号337页码:17
关键词Rosa chinensis Polysaccharide Nonalcoholic steatohepatitis HMGB1
ISSN号0144-8617
DOI10.1016/j.carbpol.2024.122139
通讯作者Ding, Kan(dingkan@simm.ac.cn)
英文摘要A novel RG-I pectin -like polysaccharide, YJ3A1, was purified from the flowers of Rosa chinensis and its structure and hepatoprotective effect in vivo and in vitro were investigated. The backbone of this polysaccharide is mainly composed of 1, 4-galactan, 1, 4 -linked alpha-Gal p A and 1, 2 -linked alpha-Rha p disaccharide repeating unit attached by 1, 6 -linked beta-Gal p or 1, 5 -linked alpha-Ara f on C-4 of the Rha p . Interestingly, oral administration of YJ3A1 significantly ameliorates NASH-associated inflammation, oxidative stress and fibrosis and does not affect the liver morphology of normal mice at a dose of 50 mg/kg. The mechanism study suggests that the biological activity may associate to inactivating of high -mobility group box 1 protein (HMGB1)/TLR4/NF- kappa B and Akt signaling pathways by restraining the expression and release of HMGB1, thereby impeding the effect of NASH. The current findings outline a novel leading polysaccharide for new drug candidate development against NASH.
WOS关键词FATTY LIVER-DISEASE ; OXIDATIVE STRESS ; ACTIVATION ; METHYLATION ; NRF2 ; L.
资助项目National Key Research and Development Program of China[2022YFA1303802] ; Shanghai Municipal Science and Technology Major Project, National Natural Science Foundation of China[32271332] ; Shanghai Municipal Science and Technology Major Project, National Natural Science Foundation of China[31870801] ; Shanghai Municipal Science and Technology Major Project, National Natural Science Foundation of China[82341097] ; High-level New R D Institute[2019B090904008] ; High-level Innovative Research Institute[2021B0909050003] ; Department of Science and Technology of Guangdong Province ; Ninth Batch of Innovative Scientific Research Team Projects from Zhongshan Science and Technology Bureau ; Zhongshan Municipal Bureau of Science and Technology
WOS研究方向Chemistry ; Polymer Science
语种英语
WOS记录号WOS:001230490600004
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/311072]  
专题新药研究国家重点实验室
通讯作者Ding, Kan
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochemistry & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China
4.Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, CAS Key Lab Receptor Res,State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Jing, Xiaoqi,Zhou, Guangqin,Zhu, Anming,et al. RG-I pectin-like polysaccharide from Rosa chinensis inhibits inflammation and fibrosis associated to HMGB1/TLR4/NF- κB signaling pathway to improve non-alcoholic steatohepatitis[J]. CARBOHYDRATE POLYMERS,2024,337:17.
APA Jing, Xiaoqi,Zhou, Guangqin,Zhu, Anming,Jin, Can,Li, Meixia,&Ding, Kan.(2024).RG-I pectin-like polysaccharide from Rosa chinensis inhibits inflammation and fibrosis associated to HMGB1/TLR4/NF- κB signaling pathway to improve non-alcoholic steatohepatitis.CARBOHYDRATE POLYMERS,337,17.
MLA Jing, Xiaoqi,et al."RG-I pectin-like polysaccharide from Rosa chinensis inhibits inflammation and fibrosis associated to HMGB1/TLR4/NF- κB signaling pathway to improve non-alcoholic steatohepatitis".CARBOHYDRATE POLYMERS 337(2024):17.

入库方式： OAI收割

来源：上海药物研究所

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