中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions

文献类型：期刊论文

作者Chaurembo, Abdallah Iddy6,7,9; Xing, Na9; Chanda, Francis6,7,9; Li, Yuan5,8; Zhang, Hui-juan4,9; Fu, Li-dan4,9; Huang, Jian-yuan3,9; Xu, Yun-jing6,7,9; Deng, Wen-hui3,9; Cui, Hao-dong2,9
刊名PHARMACOLOGICAL RESEARCH
出版日期2024-05-01
卷号203页码:20
关键词Mitofilin Cristae junction Mitochondrial dysfunction Cardiovascular diseases Mitochondrial-targeted therapy
ISSN号1043-6618
DOI10.1016/j.phrs.2024.107164
通讯作者Xing, Na(xingna@zidd.ac.cn) ; Lin, Han-bin(linhanbin@simm.ac.cn)
英文摘要The impact of mitochondrial dysfunction on the pathogenesis of cardiovascular disease is increasing. However, the precise underlying mechanism remains unclear. Mitochondria produce cellular energy through oxidative phosphorylation while regulating calcium homeostasis, cellular respiration, and the production of biosynthetic chemicals. Nevertheless, problems related to cardiac energy metabolism, defective mitochondrial proteins, mitophagy, and structural changes in mitochondrial membranes can cause cardiovascular diseases via mitochondrial dysfunction. Mitofilin is a critical inner mitochondrial membrane protein that maintains cristae structure and facilitates protein transport while linking the inner mitochondrial membrane, outer mitochondrial membrane, and mitochondrial DNA transcription. Researchers believe that mitofilin may be a therapeutic target for treating cardiovascular diseases, particularly cardiac mitochondrial dysfunctions. In this review, we highlight current findings regarding the role of mitofilin in the pathogenesis of cardiovascular diseases and potential therapeutic compounds targeting mitofilin.
WOS关键词MITOCHONDRIAL INNER MEMBRANE ; LEFT-VENTRICULAR HYPERTROPHY ; REDUCED EJECTION FRACTION ; HEART-FAILURE ; CELL-DEATH ; CARDIAC-HYPERTROPHY ; CONTACT SITE ; MOLECULAR-MECHANISMS ; REPERFUSION INJURY ; ORGANIZING SYSTEM
资助项目ANSO Scholarship for Young Talents[2022ANSOM123] ; National Natural Science Foundation of China[82100391] ; High-level New R D Institute[2019B090904008] ; High-level Innovative Research Institute[2021B0909050003]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001226683700001
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/311075]  
专题中国科学院上海药物研究所
通讯作者Xing, Na; Lin, Han-bin
作者单位1.Shenyang Agr Univ, Food Sci Coll, Shenyang, Liaoning, Peoples R China
2.Guizhou Med Univ, Guiyang, Guizhou, Peoples R China
3.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China
4.Zunyi Med Univ, Sch Pharm, Zunyi, Guizhou, Peoples R China
5.Guangzhou Univ Chinese Med, Guangzhou, Guangdong, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat, Stake Key Lab Chem Biol, Med, Shanghai, Peoples R China
8.Guangzhou Univ Tradit Chinese Med, Zhongshan Hosp Tradit Chinese Med, Dept Cardiol, Zhongshan, Guangdong, Peoples R China
9.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, 10 Heqing Rd, Zhongshan, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Chaurembo, Abdallah Iddy,Xing, Na,Chanda, Francis,et al. Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions[J]. PHARMACOLOGICAL RESEARCH,2024,203:20.
APA Chaurembo, Abdallah Iddy.,Xing, Na.,Chanda, Francis.,Li, Yuan.,Zhang, Hui-juan.,...&Lin, Kai-xuan.(2024).Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions.PHARMACOLOGICAL RESEARCH,203,20.
MLA Chaurembo, Abdallah Iddy,et al."Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions".PHARMACOLOGICAL RESEARCH 203(2024):20.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。