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Annamiacids A and B: Two dissymmetric bis-diterpenes containing a rare ketal- γ-lactone motif from Podocarpus annamiensis and their inhibitory effects on ATP-citrate lyase

文献类型：期刊论文

作者Song, Chi2,3; Zhao, Ze-Yu2,3; Zhu, Jin-Xin2; Zang, Yi1; Xiong, Juan3; Li, Jia1; Hu, Jin-Feng2,3
刊名PHYTOCHEMISTRY LETTERS
出版日期2024-06-01
卷号61页码:142-148
关键词Podocarpus annamiensis Podocarpaceae Endangered conifer Annamiacids Bis-diterpenes ATP citrate lyase
ISSN号1874-3900
DOI10.1016/j.phytol.2024.04.010
通讯作者Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@fudan.edu.cn)
英文摘要Two undescribed dissymmetric bis-diterpenes, annamiacids A (1) and B (2), were isolated from the renewable twigs and leaves of Podocarpus annamiensis, a 'vulnerable' conifer endemic to China. Their structures and absolute configurations were determined by spectroscopic and computational methods. The homodimeric (abietane-O-abietane, 1) and heterodimeric (abietane-O-totarane, 2) dimers were constructed from an identical phenolic abietane unit through an ether linkage with a phenolic abietane acid and a phenolic totarane acid, respectively. Both comprise a rare intramolecular 6-ketal-19,6-gamma-lactone motif. Compound 2 could significantly inhibit ATP-citrate lyase with an IC50 value of 5.92 mu M. A molecular docking study disclosed alternative Hbonds/interacting amino acid residues and binding pockets between 2 and the ACL enzyme when compared with those of compound 1, which supports their in vitro data.
WOS关键词DIMERIC ABIETANE ; BARK
资助项目NSFC[21937002] ; NSFC[81773599] ; Zhejiang Provincial Natural Science Foundation of China[LY23H300001]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001230772100002
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/311078]  
专题新药研究国家重点实验室
通讯作者Xiong, Juan; Hu, Jin-Feng
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Taizhou Univ, Inst Nat Med & Hlth Prod, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Evolutionary Ecol & Co, Taizhou 318000, Zhejiang, Peoples R China
3.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Song, Chi,Zhao, Ze-Yu,Zhu, Jin-Xin,et al. Annamiacids A and B: Two dissymmetric bis-diterpenes containing a rare ketal- γ-lactone motif from Podocarpus annamiensis and their inhibitory effects on ATP-citrate lyase[J]. PHYTOCHEMISTRY LETTERS,2024,61:142-148.
APA Song, Chi.,Zhao, Ze-Yu.,Zhu, Jin-Xin.,Zang, Yi.,Xiong, Juan.,...&Hu, Jin-Feng.(2024).Annamiacids A and B: Two dissymmetric bis-diterpenes containing a rare ketal- γ-lactone motif from Podocarpus annamiensis and their inhibitory effects on ATP-citrate lyase.PHYTOCHEMISTRY LETTERS,61,142-148.
MLA Song, Chi,et al."Annamiacids A and B: Two dissymmetric bis-diterpenes containing a rare ketal- γ-lactone motif from Podocarpus annamiensis and their inhibitory effects on ATP-citrate lyase".PHYTOCHEMISTRY LETTERS 61(2024):142-148.

入库方式： OAI收割

来源：上海药物研究所

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