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Gastroretentive Raft Forming System for Enhancing Therapeutic Effect of Drug-Loaded Hollow Mesoporous Silica on Gastric Ulcers

文献类型：期刊论文

作者Chen, Huayuan5,6; Pan, Li4; Zhang, Chengyu3; Liu, Lin5,6; Tu, Bin2; Liu, Ergang5; Huang, Yongzhuo1,2,3,5,6
刊名ADVANCED HEALTHCARE MATERIALS
出版日期2024-05-20
页码14
关键词gastric ulcers gastroretentive raft forming system hollow mesoporous silica patchouli alcohol pyroptosis
ISSN号2192-2640
DOI10.1002/adhm.202400566
通讯作者Liu, Ergang(liuergang@zidd.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Gastric ulcers are characterized by damage to the stomach lining and are often triggered by substances such as ethanol and non-steroidal anti-inflammatory drugs. Patchouli alcohol (PA) has demonstrated effectiveness in treating gastric ulcers through antioxidative and anti-inflammatory effects. However, the water insolubility of PA and rapid gastric emptying cause low drug concentration and poor absorption in the stomach, resulting in limited treatment efficacy of PA. This study develops an oral gastroretentive raft forming system (GRFDDS) containing the aminated hollow mesoporous silica nanoparticles (NH2-HMSN) for PA delivery. The application of NH2-HMSN can enhance PA-loading capacity and water dispersibility, promoting bio-adhesion to the gastric mucosa and sustained drug release. The incorporation of PA-loaded NH2-HMSN (NH2-HMSN-PA) into GRFDDS can facilitate gastric drug retention and achieve long action, thereby improving therapeutic effects. The results reveal that NH2-HMSN-PA protects the gastric mucosa damage by inhibiting NLRP3-mediated pyroptosis. The GRFDDS, optimized through orthogonal design, demonstrates the gastric retention capacity and sustained drug release, exhibiting significant therapy efficacy in an ethanol-induced acute gastric ulcers model and an aspirin-induced chronic gastric ulcers model through antioxidation, anti-pyroptosis, and anti-inflammation. This study provides a potential strategy for enhancing druggability of insoluble natural compounds and therapeutic management of gastric ulcers. This study develops an oral gastroretentive raft forming system (GRFDDS) containing the aminated hollow mesoporous silica nanoparticles (NH2-HMSN) for delivery of patchouli alcohol (PA) for the treatment of gastric ulcers. image
WOS关键词SOLID DISPERSIONS ; DELIVERY ; PH ; NANOPARTICLES ; INHIBITION ; POLYMERS ; DISEASES ; CARRIER ; STRESS ; DESIGN
资助项目National Key Research and Development Program of China ; National Natural Science Foundation of China[82204282] ; National Natural Science Foundation of China[81925035] ; Department of Science and Technology of Guangdong Province (High-level new RD institute)[2019B090904008] ; Department of Science and Technology of Guangdong Province (High-level new RD institute)[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011] ; [2021YFE0103100] ; [2021YFC2400600]
WOS研究方向Engineering ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001227000200001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/311084]  
专题新药研究国家重点实验室
通讯作者Liu, Ergang; Huang, Yongzhuo
作者单位1.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, 12 Jichang Rd, Guangzhou 510450, Peoples R China
4.Zunyi Med Univ, Sch Pharm, Zunyi 563003, Peoples R China
5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
6.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Huayuan,Pan, Li,Zhang, Chengyu,et al. Gastroretentive Raft Forming System for Enhancing Therapeutic Effect of Drug-Loaded Hollow Mesoporous Silica on Gastric Ulcers[J]. ADVANCED HEALTHCARE MATERIALS,2024:14.
APA Chen, Huayuan.,Pan, Li.,Zhang, Chengyu.,Liu, Lin.,Tu, Bin.,...&Huang, Yongzhuo.(2024).Gastroretentive Raft Forming System for Enhancing Therapeutic Effect of Drug-Loaded Hollow Mesoporous Silica on Gastric Ulcers.ADVANCED HEALTHCARE MATERIALS,14.
MLA Chen, Huayuan,et al."Gastroretentive Raft Forming System for Enhancing Therapeutic Effect of Drug-Loaded Hollow Mesoporous Silica on Gastric Ulcers".ADVANCED HEALTHCARE MATERIALS (2024):14.

入库方式： OAI收割

来源：上海药物研究所

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