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Exploring the Link Between Exogenous Thyroid Hormones and Dementia Symptoms: A Real-World Disproportionality Analysis of FDA Adverse Event Reporting System

文献类型：期刊论文

作者Zhou, Jianxing1,2,3; Lai, Weipeng3; Wei, Zipeng2,3; Xu, Baohua2,3; Liu, Maobai2,3; Zhang, Nanwen3; Wu, Xuemei2,3
刊名ANNALS OF PHARMACOTHERAPY
出版日期2024-05-16
页码11
关键词thyroid hormones dementia pharmacovigilance FAERS database thyroid disorders
ISSN号1060-0280
DOI10.1177/10600280241252211
通讯作者Wu, Xuemei(wuxuemei@fjmu.edu.cn)
英文摘要Background: A growing body of evidence indicates a strong association between exogenous thyroid hormone (ETH) and brain health. Establishing the potential relationship between ETH therapy and dementia symptoms is crucial for patients with thyroid disorders.Objective: In this study, we investigate the potential association between ETH therapy and dementia symptoms by exploring the Food and Drug Administration Adverse Event Reporting System (FAERS) database.Methods: Disproportionality analysis (DPA) was conducted using postmarketing data from the FAERS repository (Q1 2004 to Q4 2023). Cases of dementia symptoms associated with ETH therapy were identified and analyzed through DPA using reporting odds ratios and information component methods. Dose and time-to-onset analyses were performed to assess the association between ETH therapy and dementia symptoms.Results: A total of 9889 cases of ETH-associated symptoms were identified in the FAERS database. Dementia accounted for a consistent proportion of adverse drug reactions each year (3.4%-6.3%). The DPA indicated an association between ETH therapy and dementia symptoms, which remained significant even across sex, age, and indications. The median time-to-onset of dementia symptoms was 7.5 days, and the median treatment time was 40.5 days. No significant dose-response relationship was observed.Conclusion and relevance: This study provides evidence for a link between ETH therapy and dementia. Clinicians are therefore advised to exercise vigilance, conduct comprehensive monitoring, and consider individualized dosing to mitigate potential reactions to ETH drug administration.
WOS关键词EPIDEMIOLOGY ; DYSFUNCTION ; HEALTH ; TRENDS
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001228106600001
出版者SAGE PUBLICATIONS INC
源URL[http://119.78.100.183/handle/2S10ELR8/311087]  
专题中国科学院上海药物研究所
通讯作者Wu, Xuemei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
2.Fujian Med Univ, Union Hosp, Dept Pharm, 29 Xinquan Rd, Fuzhou 350001, Fujian, Peoples R China
3.Fujian Med Univ, Sch Pharm, Fuzhou, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Jianxing,Lai, Weipeng,Wei, Zipeng,et al. Exploring the Link Between Exogenous Thyroid Hormones and Dementia Symptoms: A Real-World Disproportionality Analysis of FDA Adverse Event Reporting System[J]. ANNALS OF PHARMACOTHERAPY,2024:11.
APA Zhou, Jianxing.,Lai, Weipeng.,Wei, Zipeng.,Xu, Baohua.,Liu, Maobai.,...&Wu, Xuemei.(2024).Exploring the Link Between Exogenous Thyroid Hormones and Dementia Symptoms: A Real-World Disproportionality Analysis of FDA Adverse Event Reporting System.ANNALS OF PHARMACOTHERAPY,11.
MLA Zhou, Jianxing,et al."Exploring the Link Between Exogenous Thyroid Hormones and Dementia Symptoms: A Real-World Disproportionality Analysis of FDA Adverse Event Reporting System".ANNALS OF PHARMACOTHERAPY (2024):11.

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来源：上海药物研究所

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