Rh(III)-Catalyzed C-H Activation/Annulation for the Construction of Quinolizinones and Indolizines
文献类型：期刊论文
| 作者 | Hou, Xinjiao4,5; Wang, Run3,4; Fang, Feifei2; Qu, Zhiyan4; Zhou, Jianhui4; Yu, Ting4; Wang, Dechuan5; Liu, Hong1,4,5 ; Zhou, Yu1,4
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2024-05-20 |
| 卷号 | 26期号:21页码:4451-4456 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.4c01160 |
| 通讯作者 | Liu, Hong(hliu@simm.ac.cn) ; Zhou, Yu(zhouyu@simm.ac.cn) |
| 英文摘要 | A catalytic-condition-controlled synthesis strategy was reported to build quinolizinone and indolizine derivatives from the easily available enamide and triazole substrates with high regioselectivity and good functional group tolerance. More especially, this transformation has successfully fulfilled a C-H bond activation of terminal olefin from enamides followed by a [3 + 3] and a [2 + 3] cyclization cascade under different catalytic conditions, respectively, to provide two kinds of potentially biologically active heterocyclic scaffolds with a ring-junction nitrogen atom. Mechanistically, the methoxyamine formyl group serves as either a traceless directing group (DG) or an oxidizing DG via the C-N and C-C cleavage in this protocol. |
| WOS关键词 | RHODIUM(III)-CATALYZED ANNULATION ; SELECTIVE SYNTHESIS ; HETEROCYCLES ; BONDS ; TRANSANNULATION ; 2-PYRIDONES ; ACTIVATION ; ALKENES ; POTENT ; ACIDS |
| 资助项目 | National Natural Science Foundation of China[82173656] ; National Natural Science Foundation of China[82151219] ; National Natural Science Foundation of China[82103969] ; National Natural Science Foundation of China |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001228051600001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311093]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Hong; Zhou, Yu |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Lingang Lab, Shanghai 200031, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Dev Ctr, Shanghai 201203, Peoples R China 5.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Xinjiao,Wang, Run,Fang, Feifei,et al. Rh(III)-Catalyzed C-H Activation/Annulation for the Construction of Quinolizinones and Indolizines[J]. ORGANIC LETTERS,2024,26(21):4451-4456. |
| APA | Hou, Xinjiao.,Wang, Run.,Fang, Feifei.,Qu, Zhiyan.,Zhou, Jianhui.,...&Zhou, Yu.(2024).Rh(III)-Catalyzed C-H Activation/Annulation for the Construction of Quinolizinones and Indolizines.ORGANIC LETTERS,26(21),4451-4456. |
| MLA | Hou, Xinjiao,et al."Rh(III)-Catalyzed C-H Activation/Annulation for the Construction of Quinolizinones and Indolizines".ORGANIC LETTERS 26.21(2024):4451-4456. |
入库方式： OAI收割
来源：上海药物研究所
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