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Supramolecular Structure of the β-Cyclodextrin Metal-Organic Framework Optimizes Iodine Stability and Its Co-delivery with l-Menthol for Antibacterial Applications

文献类型：期刊论文

作者Zhao, Xiangyu4,5,6; Li, Tianfu3,4,5; Guo, Tao5; He, Xiaojian2,4,5; Ren, Xiaohong5; Wang, Manli2,5; Wang, Caifen3,5; Peng, Can4,6; Zhang, Jiwen1,2,3,5,6; Wu, Li1,3,4,5,6
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2024-04-30
卷号16期号:19页码:24235-24247
关键词cyclodextrin metal-organic framework iodine stability molecular docking co-delivery upper respiratory tract
ISSN号1944-8244
DOI10.1021/acsami.4c02258
通讯作者Peng, Can(pengcan@ahtcm.edu.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) ; Wu, Li(wuli@simm.ac.cn)
英文摘要The spread of upper respiratory tract (URT) infections harms people's health and causes social burdens. Developing targeted treatment strategies for URT infections that exhibit good biocompatibility, stability, and strong antimicrobial effects remains challenging. The dual antimicrobial and antiviral effects of iodine (I-2) in combination with the cooling sensation of l-menthol in the respiratory tract can simultaneously alleviate URT inflammation symptoms. However, as both I-2 and l-menthol are volatile, addressing stability issues is crucial. In this study, a potassium iodide beta-cyclodextrin metal-organic framework [beta-CD-POF(I)] with appropriate particle size was used to coload and deliver I-2 and l-menthol. Primarily, beta-CD-POF(I) was employed as the most efficient carrier to significantly enhance the stability of I-2, surpassing any other known protection strategies in the pharmaceutical field (CD complexations, PVP conjugations, and cadexomer iodine). The mechanism underlying the improvement in stability of I-2 by beta-CD-POF(I) was investigated through scanning electron microscopy with energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, and molecular docking. The results revealed that the key processes involved in improving stability were the inclusion of I-2 by beta-CD cavities in beta-CD-POF(I) and the formation of polyiodide anion between iodine ions and I-2. Furthermore, the potential of beta-CD-POF(I) to load and deliver drugs was validated, and coloading of l-menthol and I-2 demonstrated reliable stability. beta-CD-POF(I) achieved a rate of URT deposition >= 95% in vitro, and the combined antibacterial effects of coloaded I-2 and l-menthol was better than I-2 or PVP-I alone, with no irritation noted following URT administration in rabbits. Therefore, the stable coloading of drugs by beta-CD-POF(I), leading to enhanced antimicrobial effects, provides a new strategy for treating URT infections.
WOS关键词POVIDONE-IODINE ; IN-VITRO ; RELEASE ; INFECTION ; CHANNEL
资助项目National Natural Science Foundation of China[82273863] ; National Natural Science Foundation of China
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001227662500001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/311099]  
专题中国科学院上海药物研究所
通讯作者Peng, Can; Zhang, Jiwen; Wu, Li
作者单位1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
2.Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China
3.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
4.Yangtze Delta Drug Adv Res Inst, Nantong 226133, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Materia Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China
6.Anhui Univ Chinese Med, Hefei 230012, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Xiangyu,Li, Tianfu,Guo, Tao,et al. Supramolecular Structure of the β-Cyclodextrin Metal-Organic Framework Optimizes Iodine Stability and Its Co-delivery with l-Menthol for Antibacterial Applications[J]. ACS APPLIED MATERIALS & INTERFACES,2024,16(19):24235-24247.
APA Zhao, Xiangyu.,Li, Tianfu.,Guo, Tao.,He, Xiaojian.,Ren, Xiaohong.,...&Wu, Li.(2024).Supramolecular Structure of the β-Cyclodextrin Metal-Organic Framework Optimizes Iodine Stability and Its Co-delivery with l-Menthol for Antibacterial Applications.ACS APPLIED MATERIALS & INTERFACES,16(19),24235-24247.
MLA Zhao, Xiangyu,et al."Supramolecular Structure of the β-Cyclodextrin Metal-Organic Framework Optimizes Iodine Stability and Its Co-delivery with l-Menthol for Antibacterial Applications".ACS APPLIED MATERIALS & INTERFACES 16.19(2024):24235-24247.

入库方式： OAI收割

来源：上海药物研究所

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