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N-Containing triterpenoid saponins from Mussaenda densiflora and identification of heinsiagenin A as a potent immunosuppressant

文献类型：期刊论文

作者Du, Xiuying3,4; Litifu, Dilinaer1,2; Yuan, Wenlong1,2; Chen, Zhongxian2,3; Chen, Zhenhua3; Zhang, Rujun3; Zuo, Jianping1,2; Lin, Zemin1,2; Zhao, Weimin2,3,4
刊名BIOORGANIC CHEMISTRY
出版日期2024-06-01
卷号147页码:9
关键词Mussaenda densiflora Triterpenoid saponin Antiosteoclastogenesis Immunosuppressive Anti-inflammatory
ISSN号0045-2068
DOI10.1016/j.bioorg.2024.107351
通讯作者Zuo, Jianping(jpzuo@simm.ac.cn) ; Lin, Zemin(linzemin@simm.ac.cn) ; Zhao, Weimin(wmzhao@simm.ac.cn)
英文摘要Eleven triterpenoid saponins, including five new compounds, which were named densiflorasides A - E (1 - 5), were isolated from aerial parts of Mussaenda densiflora (Rubiaceae). Their structures were elucidated based on spectroscopic and single-crystal X-ray diffraction analyses and chemical methods. All the isolated compounds and the aglycone heinsiagenin A were evaluated for their immunosuppressive and antiosteoclastogenic activities in vitro. Compounds 6 - 8 and heinsiagenin A inhibited osteoclastogenesis, with IC50 values ranging from 8.24 to 17.7 mu M. Furthermore, compounds 3, 6 - 8, and heinsiagenin A significantly inhibited T-cell proliferation, with IC50 values ranging from 2.56 to 8.60 mu M, and compounds 3 - 5 and 11 inhibited the proliferation of B lymphocytes, with IC50 values ranging from 1.29 to 8.49 mu M. Further in vivo experiments indicated that heinsiagenin A could significantly attenuate IMQ-induced psoriasis and DSS-induced colitis in mice.
WOS关键词GLYCOSIDES
资助项目National Engineering Research Center of TCM Standardization Technology ; Shanghai Institute of Materia Medica ; Chinese Academy of Sciences[2023-ZYBZH-03] ; National Natural Science Foundation of China[82374108]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001224838700002
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/311237]  
专题新药研究国家重点实验室
通讯作者Zuo, Jianping; Lin, Zemin; Zhao, Weimin
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China
4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Du, Xiuying,Litifu, Dilinaer,Yuan, Wenlong,et al. N-Containing triterpenoid saponins from Mussaenda densiflora and identification of heinsiagenin A as a potent immunosuppressant[J]. BIOORGANIC CHEMISTRY,2024,147:9.
APA Du, Xiuying.,Litifu, Dilinaer.,Yuan, Wenlong.,Chen, Zhongxian.,Chen, Zhenhua.,...&Zhao, Weimin.(2024).N-Containing triterpenoid saponins from Mussaenda densiflora and identification of heinsiagenin A as a potent immunosuppressant.BIOORGANIC CHEMISTRY,147,9.
MLA Du, Xiuying,et al."N-Containing triterpenoid saponins from Mussaenda densiflora and identification of heinsiagenin A as a potent immunosuppressant".BIOORGANIC CHEMISTRY 147(2024):9.

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来源：上海药物研究所

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