Charting new paradigms for CAR-T cell therapy beyond current Achilles heels
文献类型：期刊论文
| 作者 | Li, Ying5; Hu, Zhenhua4; Li, Yuanyuan1,2,3; Wu, Xiaoyan5 |
| 刊名 | FRONTIERS IN IMMUNOLOGY
 |
| 出版日期 | 2024-05-01 |
| 卷号 | 15页码:12 |
| 关键词 | chimeric antigen receptor immunotherapy allogeneic universal CAR-T cells in vivo CAR-T cell Achilles heels |
| ISSN号 | 1664-3224 |
| DOI | 10.3389/fimmu.2024.1409021 |
| 通讯作者 | Hu, Zhenhua(huzhh@nfu.edu.cn) ; Li, Yuanyuan(liyuanyuan@simm.ac.cn) ; Wu, Xiaoyan(xwu@hust.edu.cn) |
| 英文摘要 | Chimeric antigen receptor-T (CAR-T) cell therapy has made remarkable strides in treating hematological malignancies. However, the widespread adoption of CAR-T cell therapy is hindered by several challenges. These include concerns about the long-term and complex manufacturing process, as well as efficacy factors such as tumor antigen escape, CAR-T cell exhaustion, and the immunosuppressive tumor microenvironment. Additionally, safety issues like the risk of secondary cancers post-treatment, on-target off-tumor toxicity, and immune effector responses triggered by CAR-T cells are significant considerations. To address these obstacles, researchers have explored various strategies, including allogeneic universal CAR-T cell development, infusion of non-activated quiescent T cells within a 24-hour period, and in vivo induction of CAR-T cells. This review comprehensively examines the clinical challenges of CAR-T cell therapy and outlines strategies to overcome them, aiming to chart pathways beyond its current Achilles heels. |
| WOS关键词 | IN-VIVO ; MANAGEMENT ; CANCER ; LEUKEMIA |
| 资助项目 | National Natural Science Foundation of China[82104252] ; Shanghai Pujiang Program[21PJ1415600] ; Guangdong Basic and Applied Basic Research Foundation[2022A1515010491] ; Zhongshan Municipal Bureau of Science and Technology ; Hubei Provincial Department of Science and Technology Project[2023BCB026] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:001222458800001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311240]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hu, Zhenhua; Li, Yuanyuan; Wu, Xiaoyan |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 4.Sun Yat Sen Univ, Nanfang Coll, Dept Hlth & Nursing, Guangzhou, Peoples R China 5.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ying,Hu, Zhenhua,Li, Yuanyuan,et al. Charting new paradigms for CAR-T cell therapy beyond current Achilles heels[J]. FRONTIERS IN IMMUNOLOGY,2024,15:12. |
| APA | Li, Ying,Hu, Zhenhua,Li, Yuanyuan,&Wu, Xiaoyan.(2024).Charting new paradigms for CAR-T cell therapy beyond current Achilles heels.FRONTIERS IN IMMUNOLOGY,15,12. |
| MLA | Li, Ying,et al."Charting new paradigms for CAR-T cell therapy beyond current Achilles heels".FRONTIERS IN IMMUNOLOGY 15(2024):12. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。