Aging-associated decrease of PGC-1α promotes pain chronification
文献类型：期刊论文
| 作者 | Wu, Xinbo1,6; Yang, Liuyue6; Li, Zihua6; Gu, Chengzheng6; Jin, Kaiyan6; Luo, Andrew6; Rasheed, Nabeel Faiyaz5; Fiutak, Isabella4; Chao, Kristina3; Chen, Amy3 |
| 刊名 | AGING CELL
 |
| 出版日期 | 2024-05-17 |
| 页码 | 16 |
| 关键词 | aging mice pain PGC-1 alpha somatosensory cortex |
| ISSN号 | 1474-9718 |
| DOI | 10.1111/acel.14177 |
| 通讯作者 | Ding, Weihua(wding@mgh.harvard.edu) ; Shen, Shiqian(sshen2@mgh.harvard.edu) |
| 英文摘要 | Aging is generally associated with declining somatosensory function, which seems at odds with the high prevalence of chronic pain in older people. This discrepancy is partly related to the high prevalence of degenerative diseases such as osteoarthritis in older people. However, whether aging alters pain processing in the primary somatosensory cortex (S1), and if so, whether it promotes pain chronification is largely unknown. Herein, we report that older mice displayed prolonged nociceptive behavior following nerve injury when compared with mature adult mice. The expression of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) in S1 was decreased in older mice, whereas PGC-1 alpha haploinsufficiency promoted prolonged nociceptive behavior after nerve injury. Both aging and PGC-1 alpha haploinsufficiency led to abnormal S1 neural dynamics, revealed by intravital two-photon calcium imaging. Manipulating S1 neural dynamics affected nociceptive behavior after nerve injury: chemogenetic inhibition of S1 interneurons aggravated nociceptive behavior in naive mice; chemogenetic activation of S1 interneurons alleviated nociceptive behavior in older mice. More interestingly, adeno-associated virus-mediated expression of PGC-1 alpha in S1 interneurons ameliorated aging-associated chronification of nociceptive behavior as well as aging-related S1 neural dynamic changes. Taken together, our results showed that aging-associated decrease of PGC-1 alpha promotes pain chronification, which might be harnessed to alleviate the burden of chronic pain in older individuals. |
| WOS关键词 | PRIMARY SOMATOSENSORY CORTEX ; INTERNEURONS ; SENSITIVITY ; EXPRESSION ; HEALTH ; NEURONS ; MICE ; AGE |
| 资助项目 | Harvard Medical School ; MGH IACUC ; Department of Anesthesia, Critical Care and Pain Medicine of MGH |
| WOS研究方向 | Cell Biology ; Geriatrics & Gerontology |
| 语种 | 英语 |
| WOS记录号 | WOS:001225583700001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311246]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ding, Weihua; Shen, Shiqian |
| 作者单位 | 1.Tongji Univ, Sch Med, Shanghai Hosp 10, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Shanghai, Peoples R China 3.Harvard Med Sch, Massachusetts Gen Hosp, Summer Intern Program, Boston, MA USA 4.Winsor Sch, Boston, MA USA 5.Univ Missouri, Sch Med, Kansas City, MO USA 6.Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Wu, Xinbo,Yang, Liuyue,Li, Zihua,et al. Aging-associated decrease of PGC-1α promotes pain chronification[J]. AGING CELL,2024:16. |
| APA | Wu, Xinbo.,Yang, Liuyue.,Li, Zihua.,Gu, Chengzheng.,Jin, Kaiyan.,...&Shen, Shiqian.(2024).Aging-associated decrease of PGC-1α promotes pain chronification.AGING CELL,16. |
| MLA | Wu, Xinbo,et al."Aging-associated decrease of PGC-1α promotes pain chronification".AGING CELL (2024):16. |
入库方式： OAI收割
来源：上海药物研究所
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