Diagnostic efficacy of [68Ga]Ga-DOTA-GPFAPI-04 in patients with solid tumors in a head-to-head comparison with [18F]F-FDG: results from a prospective clinical study
文献类型：期刊论文
| 作者 | Yuan, Hui6; Liu, Entao6; Zhang, Guojin6; Lai, Chaoquan5; Zhang, Qing6; Shang, Yuxiang6; Cheng, Zhen2,3,4; Jiang, Lei1,6 |
| 刊名 | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
 |
| 出版日期 | 2024-05-10 |
| 页码 | 13 |
| 关键词 | FAPI [Ga-68]Ga PET Gly-pro sequence |
| ISSN号 | 1619-7070 |
| DOI | 10.1007/s00259-024-06756-0 |
| 通讯作者 | Cheng, Zhen(zcheng@simm.ac.cn) ; Jiang, Lei(leijiang1031@163.com) |
| 英文摘要 | Purpose To identify the biodistribution and diagnostic performance of a novel fibroblast activation protein (FAP) targeted positron emission tomography (PET) tracer, [Ga-68]Ga-DOTA-GPFAPI-04, in patients with solid tumors in a head-to-head comparison with [F-18]F-FDG. Methods Twenty-six patients histologically proven with cancers of nasopharyngeal (n = 5), esophagus (n = 5), gastro-esophagus (n = 1), stomach (n = 7), liver (n = 3), and colorectum (n = 5) were recruited for [Ga-68]Ga-DOTA-GPFAPI-04 and [F-18]F-FDG PET/CT scans on consecutive days. The primary endpoint was the diagnostic efficacy, with the histological diagnosis and the follow-up results selected as the gold standard. The secondary endpoint was the background uptake pattern. Two experienced nuclear medicine physicians who were blinded to the gold standard results while having essential awareness of the clinical context reviewed the images and labeled lesions by consensus for subsequent software-assisted lesion segmentation. Additionally, background organs were automatically segmented, assisted by artificial intelligence. Volume, mean, and maximum standard uptake values (SUVmean and SUVmax) of all segmentations were recorded. P < 0.05 was deemed as statistically significant. Results Significant glandular uptake of [Ga-68]Ga-DOTA-GPFAPI-04 was detected in the thyroid, pancreas, and submandibular glands, while moderate uptake was observed in the parotid glands. The myocardium and myometrium exhibited 2-3 times higher uptake of the radiotracer than that of the background levels in blood and liver. A total of 349 targeted lesions, consisting of 324 malignancies and 25 benign lesions, were segmented. [Ga-68]Ga-DOTA-GPFAPI-04 is more sensitive than [F-18]F-FDG, especially for abdominopelvic dissemination (1.000 vs. 0.475, P < 0.001). Interestingly, [F-18]F-FDG demonstrated higher sensitivity for lung metastasis compared to [Ga-68]Ga-DOTA-GPFAPI-04 (0.845 vs. 0.682, P = 0.003). The high glandular uptake made it difficult to delineate lesions in close proximity and masked two metastatic lesions in these organs. Conclusion Despite prominent glandular uptake, [Ga-68]Ga-DOTA-GPFAPI-04 demonstrates favorable diagnostic performance. It is a promising probe scaffold for further development of FAP-targeted tumor theranostic agents. |
| WOS关键词 | GA-68-FAPI-04 ; PET/CT ; SCALE |
| 资助项目 | National Natural Science Foundation of China |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:001220871600001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311252]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Cheng, Zhen; Jiang, Lei |
| 作者单位 | 1.Guangdong Prov Key Lab Artificial Intelligence Med, Guangzhou, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai, Shandong, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai, Peoples R China 5.Northeastern Univ, Inst Mol Med, Coll Life & Hlth Sci, Shenyang, Peoples R China 6.Southern Med Univ, Guangdong Prov Peoples Hosp, PET Ctr, Dept Nucl Med,Guangdong Acad Med Sci, 106 Zhongshan Er Rd, Guangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Hui,Liu, Entao,Zhang, Guojin,et al. Diagnostic efficacy of [68Ga]Ga-DOTA-GPFAPI-04 in patients with solid tumors in a head-to-head comparison with [18F]F-FDG: results from a prospective clinical study[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2024:13. |
| APA | Yuan, Hui.,Liu, Entao.,Zhang, Guojin.,Lai, Chaoquan.,Zhang, Qing.,...&Jiang, Lei.(2024).Diagnostic efficacy of [68Ga]Ga-DOTA-GPFAPI-04 in patients with solid tumors in a head-to-head comparison with [18F]F-FDG: results from a prospective clinical study.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,13. |
| MLA | Yuan, Hui,et al."Diagnostic efficacy of [68Ga]Ga-DOTA-GPFAPI-04 in patients with solid tumors in a head-to-head comparison with [18F]F-FDG: results from a prospective clinical study".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2024):13. |
入库方式： OAI收割
来源：上海药物研究所
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