Ciliatonoids D-M, highly modified limonoids from the twigs of Toona ciliata
文献类型：期刊论文
| 作者 | Liu, Cui-Ping3; Gao, Yuan2,3; Li, Wen-Jing3; Xu, Cheng-Hui3; Liu, Qun-Fang3 ; Ding, Jian3; Zhao, Jin-Xin1,3; Yue, Jian-Min1,3
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2024-04-28 |
| 卷号 | 156页码:10 |
| 关键词 | Toona ciliata Meliaceae Limonoid ML-J-DP4 Ciliatonoids D-M Cytotoxicity |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2024.133942 |
| 通讯作者 | Zhao, Jin-Xin(jxzhao@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | A new ring-intact limonoid, ciliatonoid D (1), five new 7,8-seco limonoids, ciliatonoids E-I (2-6), three new 7,8seco-29-nor limonoids, ciliatonoids J-L (7-9), and a new 7,8:9,11-diseco limonoid, ciliatonoid M (10), together with eleven known limonoids were isolated from the twigs of Toona ciliata. Their structures were established by comprehensive analyses of spectroscopic, electronic circular dichroism, single-crystal X-ray diffraction data. Compound 6 bears an uncommon 1,30-oxygen bridge. Compound 10 represents a rare example of a structure with 9,11-seco limonoid from Meliaceae. The orientation of the 14,15-epoxy moiety in a known limonoid, toonayunnanae C (12), was revised as in a beta-orientation by quantum NMR calculations with ML-J-DP4 probability analysis. Compound 9 and a known analogue, toonanoronoid C (11), were found to show modest in vitro cytotoxicity against HL-60 (human premyelocytic leukemia) and P-388 (murine leukemia) cell lines. |
| WOS关键词 | LEAVES ; DITERPENOIDS ; SEEDS ; STEMS |
| 资助项目 | National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[T2192972] ; Youth Innovation Pro- motion Association of CAS[2022282] ; Shandong Laboratory Program[SYS202205] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001224691300001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311258]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Jin-Xin; Yue, Jian-Min |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, 198 East Binhai Rd, Yantai 264117, Shandong, Peoples R China 2.Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Cui-Ping,Gao, Yuan,Li, Wen-Jing,et al. Ciliatonoids D-M, highly modified limonoids from the twigs of Toona ciliata[J]. TETRAHEDRON,2024,156:10. |
| APA | Liu, Cui-Ping.,Gao, Yuan.,Li, Wen-Jing.,Xu, Cheng-Hui.,Liu, Qun-Fang.,...&Yue, Jian-Min.(2024).Ciliatonoids D-M, highly modified limonoids from the twigs of Toona ciliata.TETRAHEDRON,156,10. |
| MLA | Liu, Cui-Ping,et al."Ciliatonoids D-M, highly modified limonoids from the twigs of Toona ciliata".TETRAHEDRON 156(2024):10. |
入库方式： OAI收割
来源：上海药物研究所
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