Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri
文献类型：期刊论文
| 作者 | You, Jin-Qiu3,4; Jin, Yun-Qi3,4; Li, Meng-Yu3,4; Zhang, Bo-Chao2; Sun, Xin-Yu1; Ding, Chun-Yong3,4; Li, Jing-Ya1 ; Hou, Ai-Jun3,4
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| 刊名 | CHINESE JOURNAL OF CHEMISTRY
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| 出版日期 | 2024-05-14 |
| 页码 | 7 |
| 关键词 | Natural products Hypericum lancasteri Meroterpenoids Structure elucidation Inflammation |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.202400248 |
| 通讯作者 | Hou, Ai-Jun(ajhou@sjtu.edu.cn) |
| 英文摘要 | Hyperlanins A (1) and B (2), two highly rearranged polycyclic polyprenylated acylphloroglucinol (PPAP)-related meroterpenoids based on different new carbon skeletons, were isolated from Hypericum lancasteri. Compound 1 incorporates an unprecedented 5/6/7/5 ring system featuring a 3,13-dioxatetracyclo[9.2.1.1(2,5).0(1,8)]pentadecane core. Compound 2 possesses a unique compact 6/6/5/6/6/5/6 ring system with a caged tetracyclo[6.2.1.1(3,8).0(5,11)]dodecane motif. Their structures were established by spectroscopic data, X-ray diffraction, and computational approaches. Both compounds showed anti-inflammatory activity in vitro. Compounds 1 and 2 could decrease the lipopolysaccharide (LPS)-/nigericin-induced IL-1 beta release in THP-1 cells. Both compounds also showed inhibition in hypoxia-inducible factor-1 alpha (HIF-1 alpha) pathway luciferase reporter assay. |
| WOS关键词 | POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS ; DERIVATIVES |
| 资助项目 | National Natural Science Foundation of China[22277074] ; Zhiyuan Future Scholar Program of Zhiyuan College, Shanghai Jiao Tong University[ZIRC2022-14] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001221743600001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311261]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hou, Ai-Jun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China 3.Shanghai Jiao Tong Univ, Natl Key Lab Innovat Immunotherapy, Shanghai 200240, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Pharmaceut Sci, Shanghai Frontiers Sci Ctr Drug Target Identificat, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | You, Jin-Qiu,Jin, Yun-Qi,Li, Meng-Yu,et al. Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri[J]. CHINESE JOURNAL OF CHEMISTRY,2024:7. |
| APA | You, Jin-Qiu.,Jin, Yun-Qi.,Li, Meng-Yu.,Zhang, Bo-Chao.,Sun, Xin-Yu.,...&Hou, Ai-Jun.(2024).Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri.CHINESE JOURNAL OF CHEMISTRY,7. |
| MLA | You, Jin-Qiu,et al."Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri".CHINESE JOURNAL OF CHEMISTRY (2024):7. |
入库方式： OAI收割
来源：上海药物研究所
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