Drymariamides A-J, Antiadipogenic Cyclopeptides Incorporating Noncanonical Amino Acids from Drymaria cordata
文献类型：期刊论文
| 作者 | Zhang, Zong-Yi2,3; Gao, Xin-Hua3; Huang, Yi2,3; Fan, Yao-Yue1,3; Yue, Jian-Min1,2,3
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2024-05-09 |
| 卷号 | 87期号:5页码:1441-1453 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.4c00246 |
| 通讯作者 | Fan, Yao-Yue(s040500290@126.com) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Herein, we report an extensive phytochemical study on the whole plant of Drymaria cordata, which led to the isolation of ten new orbitides, named drymariamides A-J (1-10). Compounds 2, 3, and 5 incorporate rare residues of noncanonical amino acids of kynurenine (Kyn) or 3a-hydroxypyrroloindoline (HPI). Their structures with absolute configurations were elucidated by a combination of spectroscopic analysis, advanced Marfey's method, X-ray diffraction, and electronic circular dichroism analysis. Compounds 1-10 exhibited antiadipogenic effects in 3T3-L1 adipocytes, and the most potent compound 7 showed an EC50 value of 1.17 +/- 0.19 mu M. |
| WOS关键词 | STRUCTURAL ELUCIDATION ; GLYCOSIDE ; OBESITY |
| 资助项目 | National Natural Science Foundation of China[2023YFE0206100] ; National Key Research and Development Program of China[22237007] ; National Key Research and Development Program of China[82122062] ; National Natural Science Foundation of China[2019-I2M-5-080] ; CAMS Innovation Fund for Medical Sciences |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001224838300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311282]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fan, Yao-Yue; Yue, Jian-Min |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zong-Yi,Gao, Xin-Hua,Huang, Yi,et al. Drymariamides A-J, Antiadipogenic Cyclopeptides Incorporating Noncanonical Amino Acids from Drymaria cordata[J]. JOURNAL OF NATURAL PRODUCTS,2024,87(5):1441-1453. |
| APA | Zhang, Zong-Yi,Gao, Xin-Hua,Huang, Yi,Fan, Yao-Yue,&Yue, Jian-Min.(2024).Drymariamides A-J, Antiadipogenic Cyclopeptides Incorporating Noncanonical Amino Acids from Drymaria cordata.JOURNAL OF NATURAL PRODUCTS,87(5),1441-1453. |
| MLA | Zhang, Zong-Yi,et al."Drymariamides A-J, Antiadipogenic Cyclopeptides Incorporating Noncanonical Amino Acids from Drymaria cordata".JOURNAL OF NATURAL PRODUCTS 87.5(2024):1441-1453. |
入库方式： OAI收割
来源：上海药物研究所
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