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Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery

文献类型：期刊论文

作者Tang, Yisi4,5,6,7; Liu, Bao6,7; Zhang, Yuting6,7; Liu, Yuling6,7; Huang, Yongzhuo1,2,3,7; Fan, Wufa6,7
刊名ADVANCED DRUG DELIVERY REVIEWS
出版日期2024-06-01
卷号209页码:20
关键词Lymphatic system Lymphatic delivery system Lymph node Protein corona Dendritic cell Vaccine
ISSN号0169-409X
DOI10.1016/j.addr.2024.115304
通讯作者Huang, Yongzhuo(yzhuang@simm.ac.cn) ; Fan, Wufa(fanwufa@imm.ac.cn)
英文摘要The lymphatic system has garnered significant attention in drug delivery research due to the advantages it offers, such as enhancing systemic exposure and enabling lymph node targeting for nanomedicines via the lymphatic delivery route. The journey of drug carriers involves transport from the administration site to the lymphatic vessels, traversing the lymph before entering the bloodstream or targeting specific lymph nodes. However, the anatomical and physiological barriers of the lymphatic system play a pivotal role in influencing the behavior and efficiency of carriers. To expedite research and subsequent clinical translation, this review begins by introducing the composition and classification of the lymphatic system. Subsequently, we explore the routes and mechanisms through which nanoparticles enter lymphatic vessels and lymph nodes. The review further delves into the interactions between nanomedicine and body fluids at the administration site or within lymphatic vessels. Finally, we provide a comprehensive overview of recent advancements in lymphatic delivery systems, addressing the challenges and opportunities inherent in current systems for delivering macromolecules and vaccines.
WOS关键词LIPID-BASED FORMULATIONS ; DENDRITIC CELLS ; SUBCUTANEOUS INJECTION ; ORAL DELIVERY ; TRANSPORT ; NODE ; ACID ; ABSORPTION ; LIPOSOMES ; EXPOSURE
资助项目National Key Research and Devel- opment Program of China[2021YFE0103100] ; National Key Research and Devel- opment Program of China[2021YFC2400600] ; National Natural Science Foundation of China[81925035] ; National Natural Science Foundation of China[82304396] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2023-RC350-01] ; CAMS Innovation Fund for Medical Sciences[2021-I2M-1-026]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001225504600001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/311288]  
专题新药研究国家重点实验室
通讯作者Huang, Yongzhuo; Fan, Wufa
作者单位1.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Peking Union Med Coll, Comparat Med Ctr, Beijing 100021, Peoples R China
5.Chinese Acad Med Sci, Inst Lab Anim Sci, NHC Key Lab Comparat Med, Natl Ctr Technol Innovat Anim Model, Beijing 100021, Peoples R China
6.Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Delivery Technol & Novel Form, Beijing 100050, Peoples R China
7.Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714		 Tang, Yisi,Liu, Bao,Zhang, Yuting,et al. Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery[J]. ADVANCED DRUG DELIVERY REVIEWS,2024,209:20.
APA Tang, Yisi,Liu, Bao,Zhang, Yuting,Liu, Yuling,Huang, Yongzhuo,&Fan, Wufa.(2024).Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery.ADVANCED DRUG DELIVERY REVIEWS,209,20.
MLA Tang, Yisi,et al."Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery".ADVANCED DRUG DELIVERY REVIEWS 209(2024):20.

入库方式： OAI收割

来源：上海药物研究所

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