Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models
文献类型：期刊论文
| 作者 | Shu, Guangzhao6; He, Yang5; Suo, Jin5 ; Wu, Chunhui1; Gong, Xudong1; Xiang, Yangyang2; Yang, Wenjiao3,4; Cheng, Jiaxin5; Wang, Yu5; Chen, Weiming6
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| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2024-03-15 |
| 卷号 | 826页码:8 |
| 关键词 | Cannabidiol Stress-induced hyperthermia Phencyclidine-induced negative symptoms of schizophrenia model 5-HT 1A receptor |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2024.137723 |
| 通讯作者 | Wang, Yu(wangyu@simm.ac.cn) ; Chen, Weiming(wader_chen@163.com) |
| 英文摘要 | Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, has been confirmed to induce anxiolytic-like and antipsychotic-like effects. However, the exact mechanisms remain unclear. This study substantiated CBD's interaction with the 5-HT1A receptor (5-HT1AR) in vitro (CHO cells expressing human 5HT1AR) and in vivo (rat lower lip retraction test, LLR test). We then assessed the impact of CBD in mice using the stress-induced hyperthermia (SIH) model and the phencyclidine (PCP)-induced negative symptoms of schizophrenia model, respectively. Concurrently, we investigated whether WAY-100635, a typical 5-HT1AR antagonist, could attenuate these effects. Furthermore, the neurotransmitter changes through high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) were studied. Results revealed that CBD exhibits selective 5-HT1AR agonists-mediated effects in the rat lower lip retraction test, aligning with the robust agonistic (EC50 = 1.75 mu M) profile observed in CHO cells. CBD at 3 mg/kg significantly reduced SIH (Delta T), a response that WAY-100635 abolished. Chronic administration of CBD at 100 mg/kg mitigated the increase in PCP-induced immobility time in the forced swim test (FST) and tail suspension test (TST). Moreover, it induced significant alterations in gamma-aminobutyric acid (GABA) and norepinephrine (NE) levels within the hippocampus (HPC). Thus, we concluded that the 5-HT1AR mediates CBD's anxiolytic-like effects. Additionally, CBD's effects on the negative symptoms of schizophrenia may be linked to changes in GABA and NE levels in the hippocampus. These findings offer novel insights for advancing the exploration of CBD's anxiolytic-like and antipsychotic-like effects. |
| WOS关键词 | STRESS-INDUCED HYPERTHERMIA ; 5-HT1A RECEPTOR ; ANXIETY ; SCHIZOPHRENIA ; PARADIGM |
| 资助项目 | Lingang Laboratory[LG-GG-202204-01] ; Lingang Laboratory[LG202103-01-04] ; STI2030-Major Projects[2021ZD0200900] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001219009800001 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311300]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Yu; Chen, Weiming |
| 作者单位 | 1.Vigonvita Life Sci Co Ltd, Shanghai 201210, Peoples R China 2.Vigonvita Life Sci Co Ltd, Suzhou 215123, Peoples R China 3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China 4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plants, Urumqi 830011, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Gannan Med Univ, Coll Pharm, Ganzhou 341000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shu, Guangzhao,He, Yang,Suo, Jin,et al. Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models[J]. NEUROSCIENCE LETTERS,2024,826:8. |
| APA | Shu, Guangzhao.,He, Yang.,Suo, Jin.,Wu, Chunhui.,Gong, Xudong.,...&Shen, Jingshan.(2024).Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models.NEUROSCIENCE LETTERS,826,8. |
| MLA | Shu, Guangzhao,et al."Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models".NEUROSCIENCE LETTERS 826(2024):8. |
入库方式： OAI收割
来源：上海药物研究所
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