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Improving the Dissolution Rate and Bioavailability of Curcumin via Co-Crystallization

文献类型：期刊论文

作者Wang, Hao2,3; Zheng, Chenxuan1,2; Tian, Fanyu2,3; Xiao, Ziyao2,3; Sun, Zhixiong1,2; Lu, Liye2; Dai, Wenjuan2; Zhang, Qi2; Mei, Xuefeng2,3
刊名PHARMACEUTICALS
出版日期2024-04-01
卷号17期号:4页码:16
关键词co-crystal curcumin L-carnitine dissolution bioavailability
DOI10.3390/ph17040489
通讯作者Zhang, Qi(qizhang@simm.ac.cn) ; Mei, Xuefeng(xuefengmei@simm.ac.cn)
英文摘要Curcumin (CUR) is a natural polyphenolic compound with various pharmacological activities. Low water solubility and bioavailability limit its clinical application. In this work, to improve the bioavailability of CUR, we prepared a new co-crystal of curcumin and L-carnitine (CUR-L-CN) via liquid-assisted grinding. Both CUR and L-CN have high safe dosages and have a wide range of applications in liver protection and animal nutrition. The co-crystal was fully characterized and the crystal structure was disclosed. Dissolution experiments were conducted in simulated gastric fluids (SGF) and simulated intestinal fluids (SIF). CUR-L-CN exhibited significantly faster dissolution rates than those of pure CUR. Hirshfeld surface analysis and wettability testing indicate that CUR-L-CN has a higher affinity for water and thus exhibits faster dissolution rates. Pharmacokinetic studies were performed in rats and the results showed that compared to pure CUR, CUR-L-CN exhibited 6.3-times-higher AUC0-t and 10.7-times-higher Cmax.
WOS关键词L-CARNITINE SUPPLEMENTATION ; PHARMACOKINETICS ; HORMONES ; STRESS
资助项目Natural Science Foundation of Shanghai
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001220401600001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/311328]  
专题中国科学院上海药物研究所
通讯作者Zhang, Qi; Mei, Xuefeng
作者单位1.Nanchang Univ, Jiangxi Med Coll, Sch Pharm, Nanchang 330006, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Ave, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Hao,Zheng, Chenxuan,Tian, Fanyu,et al. Improving the Dissolution Rate and Bioavailability of Curcumin via Co-Crystallization[J]. PHARMACEUTICALS,2024,17(4):16.
APA Wang, Hao.,Zheng, Chenxuan.,Tian, Fanyu.,Xiao, Ziyao.,Sun, Zhixiong.,...&Mei, Xuefeng.(2024).Improving the Dissolution Rate and Bioavailability of Curcumin via Co-Crystallization.PHARMACEUTICALS,17(4),16.
MLA Wang, Hao,et al."Improving the Dissolution Rate and Bioavailability of Curcumin via Co-Crystallization".PHARMACEUTICALS 17.4(2024):16.

入库方式： OAI收割

来源：上海药物研究所

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