Rocaglamide regulates iron homeostasis by suppressing hepcidin expression
文献类型：期刊论文
| 作者 | Zhu, Xinyue4,5; Zuo, Quan2,3; Xie, Xueting4,5; Chen, Zhongxian2,3; Wang, Lixin4,5; Chang, Linyue2,3; Liu, Yangli4,5; Luo, Jiaojiao4,5; Fang, Cheng4,5; Che, Linlin4,5 |
| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
 |
| 出版日期 | 2024-07-01 |
| 卷号 | 219页码:153-162 |
| 关键词 | Rocaglamide Hepcidin Iron homeostasis Anemia of inflammation IL-6/STAT3 pathway |
| ISSN号 | 0891-5849 |
| DOI | 10.1016/j.freeradbiomed.2024.04.232 |
| 通讯作者 | Zhao, Weimin(wmzhao@simm.ac.cn) ; Zhou, Yufu(zhouyufu@shutcm.edu.cn) ; Zhu, Shiguo(zhushiguo@shutcm.edu.cn) |
| 英文摘要 | The anemia of inflammation (AI) is characterized by the presence of inflammation and abnormal elevation of hepcidin. Accumulating evidence has proved that Rocaglamide (RocA) was involved in inflammation regulation. Nevertheless, the role of RocA in AI, especially in iron metabolism, has not been investigated, and its underlying mechanism remains elusive. Here, we demonstrated that RocA dramatically suppressed the elevation of hepcidin and ferritin in LPS-treated mice cell line RAW264.7 and peritoneal macrophages. In vivo study showed that RocA can restrain the depletion of serum iron (SI) and transferrin (Tf) saturation caused by LPS. Further investigation showed that RocA suppressed the upregulation of hepcidin mRNA and downregulation of Fpn1 protein expression in the spleen and liver of LPS-treated mice. Mechanistically, this effect was attributed to RocA ' s ability to inhibit the IL-6/STAT3 pathway, resulting in the suppression of hepcidin mRNA and subsequent increase in Fpn1 and TfR1 expression in LPS-treated macrophages. Moreover, RocA inhibited the elevation of the cellular labile iron pool (LIP) and reactive oxygen species (ROS) induced by LPS in RAW264.7 cells. These findings reveal a pivotal mechanism underlying the roles of RocA in modulating iron homeostasis and also provide a candidate natural product on alleviating AI. |
| WOS关键词 | INFLAMMATION ; TRANSFERRIN ; RECEPTOR ; ANEMIA |
| 资助项目 | National Natural Science Foundation of China[82373908] ; National Natural Science Foundation of China[22377137] ; Natural Science Foundation of Shanghai[22ZR1461600] ; Natural Science Foundation of Shanghai[23ZR1460800] ; Xinglin Scholar of Shanghai University of Traditional Chinese Medicine[A2-X1904426] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:001217979900001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311349]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhao, Weimin; Zhou, Yufu; Zhu, Shiguo |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, 1200 CaiLun Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Ctr Tradit Chinese Med & Immunol Res, Sch Integrat Med, Shanghai 201203, Peoples R China 5.Shanghai Univ Tradit Chinese Med, Sch Basic Med, Dept Immunol & Pathogen Biol, 1200 CaiLun Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Xinyue,Zuo, Quan,Xie, Xueting,et al. Rocaglamide regulates iron homeostasis by suppressing hepcidin expression[J]. FREE RADICAL BIOLOGY AND MEDICINE,2024,219:153-162. |
| APA | Zhu, Xinyue.,Zuo, Quan.,Xie, Xueting.,Chen, Zhongxian.,Wang, Lixin.,...&Zhu, Shiguo.(2024).Rocaglamide regulates iron homeostasis by suppressing hepcidin expression.FREE RADICAL BIOLOGY AND MEDICINE,219,153-162. |
| MLA | Zhu, Xinyue,et al."Rocaglamide regulates iron homeostasis by suppressing hepcidin expression".FREE RADICAL BIOLOGY AND MEDICINE 219(2024):153-162. |
入库方式： OAI收割
来源：上海药物研究所
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