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Deciphering Authentic Nociceptive Thalamic in Rats

文献类型：期刊论文

作者Li, Zhenjiang1,2; Zhang, Libo1,2; Zhang, Fengrui1,2; Yue, Lupeng1,2; Hu, Li1,2
刊名RESEARCH
出版日期2024-04-09
卷号7页码:15
ISSN号2096-5168
DOI10.34133/research.0348
通讯作者Hu, Li(huli@psych.ac.cn)
英文摘要The thalamus and its cortical connections play a pivotal role in pain information processing, yet the exploration of its electrophysiological responses to nociceptive stimuli has been limited. Here, in 2 experiments we recorded neural responses to nociceptive laser stimuli in the thalamic (ventral posterior lateral nucleus and medial dorsal nucleus) and cortical regions (primary somatosensory cortex [S1] and anterior cingulate cortex) within the lateral and medial pain pathways. We found remarkable similarities in laser-evoked brain responses that encoded pain intensity within thalamic and cortical regions. Contrary to the expected temporal sequence of ascending information flow, the recorded thalamic response (N1) was temporally later than its cortical counterparts, suggesting that it may not be a genuine thalamusgenerated response. Importantly, we also identified a distinctive component in the thalamus, i.e., the early negativity (EN) occurring around 100 ms after the onset of nociceptive stimuli. This EN component represents an authentic nociceptive thalamic response and closely synchronizes with the directional information flow from the thalamus to the cortex. These findings underscore the importance of isolating genuine thalamic neural responses, thereby contributing to a more comprehensive understanding of the thalamic function in pain processing. Additionally, these findings hold potential clinical implications, particularly in the advancement of closed-loop neuromodulation treatments for neurological diseases targeting this vital brain region.
收录类别SCI
WOS关键词PRIMARY SOMATOSENSORY CORTEX ; ELECTROPHYSIOLOGICAL RESPONSES ; PAIN ; BRAIN ; OSCILLATIONS ; STIMULATION ; MEDIODORSAL ; NEURONS ; SIGNALS ; EEG
资助项目Beijing Natural Science Foundation[JQ22018] ; National Natural Science Foundation of China[32071061] ; STl2030-Major Projects[2022ZD0206400]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001242424700001
出版者AMER ASSOC ADVANCEMENT SCIENCE
资助机构Beijing Natural Science Foundation ; National Natural Science Foundation of China ; STl2030-Major Projects
源URL[http://ir.psych.ac.cn/handle/311026/48046]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Hu, Li
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Li, Zhenjiang,Zhang, Libo,Zhang, Fengrui,et al. Deciphering Authentic Nociceptive Thalamic in Rats[J]. RESEARCH,2024,7:15.
APA Li, Zhenjiang,Zhang, Libo,Zhang, Fengrui,Yue, Lupeng,&Hu, Li.(2024).Deciphering Authentic Nociceptive Thalamic in Rats.RESEARCH,7,15.
MLA Li, Zhenjiang,et al."Deciphering Authentic Nociceptive Thalamic in Rats".RESEARCH 7(2024):15.

入库方式： OAI收割

来源：心理研究所

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