Interaction of childhood trauma with BDNF and FKBP5 gene polymorphisms in predicting burnout in general occupational groups
文献类型：期刊论文
| 作者 | Li, Yuling4,5,6,7,8; Jia, Haiying3; Wei, Xueqian4,5; Zhen, Shiqian2; He, Shu-Chang4,5; Zhang, Xiang Yang1
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| 刊名 | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
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| 出版日期 | 2024-06-11 |
| 页码 | 10 |
| 关键词 | Burnout BDNF gene FKBP5 gene Childhood trauma Gene-by-environment (G x E) interaction Gene-by-gene-by-environment (G x G x E) interaction |
| ISSN号 | 0940-1334 |
| DOI | 10.1007/s00406-024-01825-9 |
| 通讯作者 | Zhen, Shiqian(zhenshiqian@caitec.org.cn) |
| 英文摘要 | Both the BDNF gene rs6265 and the FKBP5 gene rs1360780 polymorphisms are independently associated with adult psychotic-like experiences, when exposed to high childhood abuse; however, it remains unclear whether the relationship between childhood abuse and burnout is moderated by these two single nucleotide polymorphisms (SNPs). Furthermore, there is an interaction between glucocorticoid receptor transcriptional activity and BDNF signaling. Therefore, we investigated the interaction of these two SNPs with childhood trauma in predicting burnout. We recruited 990 participants (mean age 33.06 years, S.D. = 6.31) from general occupational groups and genotyped them for rs6265 and rs1360780. Burnout, childhood trauma, resilience, and job stress were measured through a series of rating scales. Gene-by-environment and gene-by-gene-by-environment interactions were examined using linear hierarchical regression and PROCESS macro in SPSS. Covariates included demographics and resilience. We found that rs6265 moderated the association between job stress and emotional exhaustion. Both rs6265 and rs1360780 moderated the association between childhood abuse and cynicism. There was significant interaction of childhood abuse x rs6265 x rs1360780 on emotional exhaustion and reduced personal accomplishment, so that rs6265 CC genotype and rs1360780 TT genotype together predicted higher levels of emotional exhaustion under high childhood abuse, while rs6265 TT genotype and rs1360780 CC genotype together exerted a resilient effect on reduced personal accomplishment in the face of childhood abuse. Our findings suggest that the rs6265 CC genotype and rs1360780 TT genotype may jointly contribute to increased risk of burnout under childhood trauma. |
| 收录类别 | SCI |
| WOS关键词 | GLUCOCORTICOID-RECEPTOR ; VAL66MET POLYMORPHISM ; RESILIENCE SCALE ; BRAIN STRUCTURE ; CHRONIC STRESS ; MALTREATMENT ; DEPRESSION ; ABUSE ; SUSCEPTIBILITY ; SYMPTOMS |
| 资助项目 | National Natural Science Foundation of China[82171862] ; National Natural Science Foundation of China[82371884] ; National Natural Science Foundation of China[23KJ08] ; Young Teachers Research Cultivation Foundation of South China Normal University |
| WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:001244720900001 |
| 出版者 | SPRINGER HEIDELBERG |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; Young Teachers Research Cultivation Foundation of South China Normal University |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48061]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhen, Shiqian |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Chinese Acad Int Trade & Econ Cooperat, Inst Circulat & Consumpt, 28 Donghou Lane, Beijing 100710, Peoples R China 3.PLA Strateg Support Force Med Ctr, Special Serv Personnel Hlth Management Dept, Beijing 100101, Peoples R China 4.Peking Univ, Beijing Key Lab Behav & Mental Hlth, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 5.Peking Univ, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 6.South China Normal Univ, Guangdong Key Lab Mental Hlth & Cognit Sci, Guangzhou 510631, Peoples R China 7.South China Normal Univ, Inst Brain Res & Rehabil, Guangzhou 510631, Peoples R China 8.South China Normal Univ, Key Lab Brain Cognit & Educ Sci, Minist Educ, Guangzhou 510631, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yuling,Jia, Haiying,Wei, Xueqian,et al. Interaction of childhood trauma with BDNF and FKBP5 gene polymorphisms in predicting burnout in general occupational groups[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2024:10. |
| APA | Li, Yuling,Jia, Haiying,Wei, Xueqian,Zhen, Shiqian,He, Shu-Chang,&Zhang, Xiang Yang.(2024).Interaction of childhood trauma with BDNF and FKBP5 gene polymorphisms in predicting burnout in general occupational groups.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,10. |
| MLA | Li, Yuling,et al."Interaction of childhood trauma with BDNF and FKBP5 gene polymorphisms in predicting burnout in general occupational groups".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2024):10. |
入库方式： OAI收割
来源：心理研究所
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